Study of biocompatibility of polybutylcyanoacrylate nanoparticles

Abstract

Abstract: Objective To evaluate the biocompatibility of polybutylcyanoacrylate nanoparticles (PBCA-NP) manufactured by emulsion polymerization technique. Methods MTT assay was performed for evaluation of the cytotoxicity of PBCA-NP (e.g. cell proliferation and hemolytic test) experiments of long-term subcutaneous implantation and implantation in the muscular tissues of PBCA-NP was conducted in rabbits to observe the inflammatory reactions due to the implantation. Results No obvious cytotoxicity or hemolytic reactions were observed (with the hemolytic rate at different concentrations of PBCA-NP<5%). Three months after PBCA-NP implantation, obvious lymphocyte infiltration was not observed in the tissues around the implants which underwent gradual degradation. Conclusion PBCA-NP possesses good biocompatibility.

CLC Number:

R979.1

YANG Xi-xiao, CHEN Jan-hai, GUO Dan. Study of biocompatibility of polybutylcyanoacrylate nanoparticles[J]. Journal of Southern Medical University, 2005, 25(10): 1261-1263.

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