Differential expression of L-type calcium channel α1 subunits on adult rat hippocampal neurons

Journal of Southern Medical University ›› 2005, Vol. 25 ›› Issue (10): 1225-1227.

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Differential expression of L-type calcium channel α1 subunits on adult rat hippocampal neurons

YANG Jian-ming¹, HU De-hui², ZHU Xin-hong¹, GAO Tian-ming¹

1. 南方医科大学神经生物学教研室, 广东, 广州, 510515;
2. 南方医科大学生理学教研室, 广东, 广州, 510515

Online:2005-10-20 Published:2005-10-20

Abstract

Abstract: Objective To study the localization of L-type calcium channel α1 subunits CaV1.2α1C and CaV1.3α1D in CA1 and CA3 regions of adult rat hippocampus. Methods Immunohistochemical staining was employed for specific labeling of α1 subunits CaV1.2α1C and CaV1.3α1D. Results CaV1.2α1C subunit was mainly located in the apical and basal dendrites in the CA1 area and the CA3 area, neuronal soma, basal dendrites and distal apical dendrites were all positively stained. In contrast to CaV1.2α1C, CaV1.3α1D displayed no obvious difference in immunostaining between CA1 and CA3, and was distributed mainly in the neuronal soma and proximal dendrites. At cellular level, CaV1.2α1C distribution showed a distinct clustered pattern while a uniform distribution was observed for CaV1.3α1D subunit. Conclusion Different α1 subunits of L-type calcium channel have differential expression in adult hippocampal neurons.

CLC Number:

R338.26

YANG Jian-ming¹, HU De-hui², ZHU Xin-hong¹, GAO Tian-ming¹. Differential expression of L-type calcium channel α1 subunits on adult rat hippocampal neurons[J]. Journal of Southern Medical University, 2005, 25(10): 1225-1227.

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Differential expression of L-type calcium channel α1 subunits on adult rat hippocampal neurons

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