Journal of Southern Medical University ›› 2006, Vol. 26 ›› Issue (10): 1458-1459.

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Prediction of the possible tertiary structure alterations of p53 protein following point mutation in p53 gene condon 282 in lung cancer cells

DU Chang-hu, XU Jun, ZHONG Nan-shan Guangzhou Respiratory Disease Institute, Guangzhou Medical College, Guangzhou 510120, China   

  1. 广州医学院第一附属医院广州呼吸疾病研究所; 广州医学院第一附属医院广州呼吸疾病研究所 广东广州510120; 广东广州510120;
  • Online:2006-10-20 Published:2006-10-20

Abstract: This study was carried out to predict the possible tertiary structure alterations of p53 protein after point mutation of p53 gene condon 282 in lung cancer cells based on the latest 3D structure analysis platform series of Phyre software. It was found that the p53 gene condon 282 mutation ( Arg/Leu) may destabilize the H2 helix and DNA binding in the major groove by compromising the contacts of p53 protein with the β-hairpin of DNA binding surface . 

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