Journal of Southern Medical University

Journal of Southern Medical University ›› 2006, Vol. 26 ›› Issue (05): 675-677.

Previous Articles     Next Articles

Expression of TGFβ1 and its type I receptors ALK1 and ALK5 mRNA in brain arteriovenous malformation

CHEN Guang-zhong1,LI Tie-lin1,QUAN Wei2,HUANG Tao1,ZHAO Qing-ping3,WANG Jian-qi1,DUAN Chuan-zhi1,WANG Qiu-jing1,JIANG Xiao-dan1 1Department of Neurosurgery,Zhujiang Hospital,Southern Medical University,Guangzhou 510282,China;2Department of Neurosurgery,First Municipal People’s Hospital of Guangzhou,Guangzhou 51000,China;3Department of Neurosurgery,Yuhuangding Hospital of Yantai,Yantai 265000,China   

  1. 南方医科大学珠江医院神经外科； 广州市第一人民医院神经外科； 山东省烟台市毓璜顶医院神经外科； 南方医科大学珠江医院神经外科 广东广州510282； 广东广州510282； 广东广州510180； 山东烟台264000；
  • Online:2006-05-20 Published:2006-05-20

PDF

1545

Abstract: Objective To explore the expression of transforming growth factor beta1(TGFβ1)and its type I receptors activin-like kinase 1(ALK1)and ALK5 mRNA in the development of brain arteriovenous malformation(BAVM).Methods The mRNA expressions of TGFβ1,ALK1and ALK5 were detected with semiquantitative RT-PCR in patients with BAVM.Results The expressions of TGFβ1 and ALK5 mRNA increased significantly in BAVM,and their relative expression quantity were 0.777±0.047 and 0.585±0.074,respectively.However,ALK1 mRNA expression declined significantlies with a relative expression of 0.173±0.044 in comparison with the control group(0.720±0.098,P<0.01).Conclusion The balance of TGFβ1 and its type I receptors ALK1 and ALK5 mRNA expressions may play important role in the development of BAVM.

CLC Number: