Expression of aquaporin-1 in a guinea pig model of labyrinth destruction

Abstract

Abstract: Objective To study the expression of aquaporin-1(AQP-1)in the cochlea and endolymphatic sac in guinea pigs with labyrinth destruction.Methods Chloroform was injected into the tympanum to establish the animal model of labyrinth destruction in guinea pigs,and two-step immunohistochemical method was used to examine the expression of AQP-1 in the cochlea and endolymphatic sac at different time points.Results AQP-1 expression was fluctuant in accordance with the morphological changes of the spiral ligament fibrocytes in the cochlea:destruction of the spiral ligament cells was followed by AQP-1 expression down-regulation,and AQP-1 up-regulation occurred with the cell regeneration.But no such changes were observed in the endolymphatic sac.Conclusion AQP-1 may take part in the maintenance of the structural stability of the spiral ligament.

CLC Number:

R-332

LI qi1,HUANG De-liang2 1Institute of Otolaryngology,2Department of Otolaryngology-Head and Neck Surgery,General Hospital of PLA,Beijing 100853,China. Expression of aquaporin-1 in a guinea pig model of labyrinth destruction[J]. Journal of Southern Medical University, 2006, 26(05): 664-666.

References

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