Abstract: Objective To evaluate the value of high-frequency echocardiography in assessing cardiac structure and function in a
mouse model of myocardial infarction. Methods Twenty-five C57BL/6 mice were randomly divided into sham-operated group
(n=10) and myocardial infarction model group (n=15) established by ligation of the left anterior descending artery. The cardiac
structure, regional wall motion and cardiac function of mice were examined with pulsed wave Doppler (PWD), tissue Doppler
imaging (TDI), EKV and M-mode echocardiography 3 days before and at 1 week after the operation. The histological changes
and myocardial structure of the heart were observed at 1 week after the operation. Results High-frequency echocardiography
and HE staining detected obvious myocardial infarction in the mice in the model group. Compared with the sham-operated
mice, the mice with myocardial infarction showed significant left ventricular expansion, obvious thinning of the ventricular
wall, and significantly decreased ventricular systolic
function and diastolic function with regional wall motion
abnormality and ventricular remodeling. Conclusions
2D-type echocardiography combined with M-mode,
PWD, TDI and EKVTM for allows accurate and sensitive
detection of the loci and severity of myocardial infarction
to provide important evidence for clinical diagnosis and
treatment of myocardial infarction.