Clinincopathological significance of homeobox BP1 mRNA expression in lung cancer tissue

Journal of Southern Medical University ›› 2006, Vol. 26 ›› Issue (08): 1173-1175.

Clinincopathological significance of homeobox BP1 mRNA expression in lung cancer tissue

XIAN Yin-sheng1, DANG Cheng-xue1, 2, YAN Chun-xia2, 3, LI He-ping1, Sidney W. Fu4, WANG Zuo-ren1 1Department of Oncology, First Affiliated Hospital, 2Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education, 3Key Laboratory of Forensic Medicine of Ministry of Public Health, Xi’an Jiaotong University, Xi’an 710061, China; 4Department of Biochemistry and Molecular Biology, George Washington University Medical Center, Washington DC 20037, USA

西安交通大学医学院第一附属医院肿瘤外科；西安交通大学医学院环境与疾病相关基因教育部重点实验室； Department of Biochemistry and Molecular Biology George Washington University Medical Center Washington DC 20037 USA；陕西西安710061；陕西西安710061西安交通大学医学院环境与疾病相关基因教育部重点实验室；陕西西安710061西安交通大学医学院卫生部法医学重点实验室；

Online:2006-08-20 Published:2006-08-20

Abstract

Abstract: Objective To investigate the expression of beta-protein 1 (BP1) gene, a novel member of DLX homeobox gene family, in lung cancer tissue and its relationship with clinical features of lung cancer. Methods RT-PCR was employed for detecting BP1 gene expression in the lung cancer tissues, adjacent tissues, non-cancer lung tissues of 46 lung cancer patients. Results Thirty-six lung cancer tissues and 6 adjacent tissues but none of the normal tissues were found to have BP1 gene overexpression, showing significant difference in BP1 expression between the tissues (P<0.01). Significant difference in BP1 gene overexpression was noted between well differentiated cancers (13 of out 21) and poorly differentiated cancers (22 of the 25), but not between cancers of different stages or between squamous carcinoma and adenocarcinoma. Conclusion BP1 gene expression is up-regulated in human lung cancer in related to the differentiation level of lung cancer but not to the clinical stage.

CLC Number:

R734.2

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Clinincopathological significance of homeobox BP1 mRNA expression in lung cancer tissue

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