Abstract: Objective To evaluate significance of different reperfusion methods in the treatment of acute ST segment elevation myocardial infarction (STEMI). Methods A retrospective analysis of the clinical data of electocardiography (ECG), echocardiogram, and angiography was conducted in 271 cases of STEMI treated in our hospital. Of these patients 31 were treated by primary percutaneous coronary intervention (PCI), and 44 by intravenous thrombolysis with urokinase, including 26 with thrombolytic treatment with concomitant PCI and 18 with rescue PCI. Results The patients receiving primary PCI, thrombolytic therapy along with PCI, and rescue PCI did not exhibit significant differences in age, sex, diabetes, hypertention, hyperlipidemia, smoking status, symptom onset to treatment time, or collateral circulation (P>0.05). The incidence of cardiac events including unstable angina, complex ventricular arrhythmia, and cardiac insufficiency were not significantly different between the 3 groups (P>0.05), nor was Killip class, number of Q waves on ECG, wall motion score, left ventricular ejection fraction, cardiac index, or stroke volume index (P>0.05). Conclusion Combination of thrombolytic therapy and interventional therapy can be a safe and effective treatment of STEMI, and rescue PCI may benefit the improvement of the left ventricular function.