Abstract: Objective To investigate whether exercise would induce myocardial ischemia in patients with coronary artery ectasia without significant coronary stenosis. Methods A total of 41 patients (male 29,female 12) with coronary artery ectasia without significant coronary stenosis,confirmed by selective coronary angiography,were enrolled in the study group.Forty-one patients with normal coronary arteries were in the control group.All the patients received a clinical examination and treadmill exercise before selective coronary angiography. Results Eighteen patients (43.9%) had typical angina in the study group with respect to two patients in the control group (χ²=10.498,P=0.001).In the study group,32 cases had positive treadmill test with respect to five cases in the control group (χ²=35.903,P<0.0001). Conclusion Patients with coronary artery ectasia without significant coronary stenosis could get typical angina.Exercise could induce myocardial ischemia which should be paid attention to.