Abstract: <Abstracts>Objective To evaluate the safety and clinical value of chorionic villus sampling via the cervix for prenatal diagnosis of early pregnancy. Method Thirty-six women with early pregnancy who required prenatal diagnosis received chorionic villus sampling via the cervix under the guidance by ultrasonography for laboratory examination of the samples. Results Villus sampling was performed successfully in 27 of the 36 cases in a single operation, whereas a second operation for sampling was needed in another 7 cases, with a total operation success rate of 94.4%. The side effects included abdominal pain and vaginal bleeding in small quantity. In the 22 women who chose to continue the pregnancy, one woman experienced miscar-riage at the 25th gestational week due to premature rupture of the membrane, and all other women gave birth to normal full-term infants. Conclusion Chorionic villus sampling via the cervix under the guidance by ultrasonography is effective and safe for prenatal diagnosis in early pregnancy to help avoid induced abortion in mid-pregnancy and the occurrence of fetal defects.