Abstract: Objective To investigate the effect of the hemostatic aerosol (HA) for emergent management of artery rupture in pigs. Methods Thirty pigs were used to establish animal models of complete femoral artery rupture by cutting off the arteries. The pigs were divided equally into 3 groups according to the hemostatic measures taken before the application of HA, namely HA spray alone, temporary hemostasis by compressing the wound with fingers, or tourniquet in another group, before HA sprays. In the late groups the finger compression or tournigut was removed 10 min after HA spray. The main indexes including average arterial blood pressure (AABP), times of spray, hemostatic time, time for membrane formation and the thickness of the HA membrane shaped while spraying, and the success rates of each method, were assessed 12 h postoperatively. Results The rate of successful hemostasis achieved by tourniquet and HA spray was 90%, 30% by finger compression and HA spray, and only 10% by direct HA spray. Conclusions For complete artery rupture, application of tourniquet for temporary hemostasis 10 min before HA spay can be the best choice for emergent management of artery rupture.