Effect of heparin on umbilical blood flow in patients with fetal growth retardation

Abstract

Abstract: Objective To investigate the effect of heparin on umbilical blood flow in pregnant women with fetal growth retardation (FGR). Methods A total of 103 FGR women wre randomized into control group (n=37), standard heparin group (n=35) and low-molecular-weight heparin group (n=31). Low-molecular-weight dextran was given in the control group, and the other two groups received agents for intervention as indicated. The umbilical blood flow, 1-minute Apgar score, body weight and gestational age of the neonates were measured and compared between the 3 groups. Results As the gestational age increases, the systolic/diastolic (S/D) ratio, pulsatility index (PI) and resistance index (RI) were significantly lowered in the two heparin groups in comparison with those in the control group (P<0.05). One-minute Apgar score and body weight of the neonates were significantly greater in the two heparin groups (P<0.05), and the gestational age was also significantly longer (P<0.05). No statistical differences in the indices measured were noted between the two heparin groups (P>0.05). Conclusions Heparin, which is safe for both the mothers and their fetuses, might improve fetal growth and development, increase neonate body weight, prolong the gestational age and raise the one-minute Apgar score.

CLC Number:

R722.6

YU Yan-hong¹, SHEN Li-yong¹, WANG Zhi-jian¹, ZHANG Yu², SU Gui-dong¹. Effect of heparin on umbilical blood flow in patients with fetal growth retardation[J]. Journal of Southern Medical University, 2004, 24(04): 423-425.

References

[1] 乐杰.妇产科学[M].第5版,北京:人民卫生出版社,2000.163-5.
[2] Harding R, Cock ML, Louey S, et al. The compromised intrauterine enviroment: implications for lung health[J]. Clin Exp Pharma Physiol, 2000,27(10):965-7.
[3] 王伊鹏,余艳红.胎儿宫内发育迟缓患者胎盘滋养细胞表面内源性血红素氧化酶的表达[J].第一军医大学学报,2002,22(7):637-9.Wang YP, Yu YH. Expression of endogenous heme oxygenase on surface of placental trophoblasts of pregnant women with intrauterine growth retardation of the fetus[J]. J First Mil Med Univ/Di Yi Jun Yi Da Xue Xue Bao, 2002, 22(7): 637-9.
[4] 刘嫒,戴笙,江森,等.胎盘细胞凋亡与胎儿生长受限关系的研究[J].中华妇产科杂志,2002,37(12):721-3.Liu Y, Dai S, Jiang S. The rationship between cell apoptosis of the placent and fetal growth retardation[J]. Chin J Obstet Gynecol, 2002,37(12): 721-3.
[5] 闻良珍,熊锦文.胎儿宫内发育迟缓的病理生理变化[J].中国实用妇科与产科杂志,2002,18(1):4-5.Wen LZ, Xiong JW. The pathophysiological change in the fetal growth retardation[J]. Chin J Pract Gynecol Obstet,2002, 18(1): 4-5.
[6] 王志坚,余艳红,沈立勇.妊高征合并胎儿宫内发育迟缓者胎盘病理改变与血管细胞粘附分子-1表达水平的关系[J].第一军医大学学报,2002,22(11):1022-4.Wang Zi, Yu YL Shen LY. Relationship between pathological changes and the expression of vascular cell adhesion molecule-1 in the placenta of patients with pregnancy-induced hypertension complicated by intrauterine growth retardation[J]. J First Mil Mead Univ/Di Yi Jun Yi Da Xue Xue Bao, 2002, 22(11): 1022-4.
[7] Bellart J, Gilabert R, Fontcuberta J, et al. Coagulation and fibrinolytic parameters in normal pregnancy and in pregnancy complicated by intrauterine growth retardation[J]. Am J Perinatol, 1998,15(1): 81-5.
[8] Bar J, Mashiah R, Cohen SB, et al. Effect of thrombophylaxis on uterine and fetal circulation in pregnant women with a history of pregnancy complications[J]. Thromb Res, 2001, 101(4): 235-41.
[9] 褚红女,黄荷凤.肝素在产科中的应用[J].中华妇产科杂志,2003,38(4):252-3.Zhu HN, Huang HF. The application of heparin in the obstetrics[J].Chin J Obstet Gynecol, 2003, 38(4): 252-3.
[10] Dulitzki M, Pauzner R, Langevitz P, et al. Low-molecular-weight heparin during pregnancy and delivery: preliminary experience with 41 pregnancies[J]. Obstet Gynecol, 1996, 87: 380-3.
[11] Dimitrakakisc C, Papageorgiou P, Papageorgiou L, et at. Absence of transplacental passage of the low molecular weight heparin in enoxaparin[J]. Hamostasis, 2000, 30(2): 243-8.