Journal of Southern Medical University ›› 2025, Vol. 45 ›› Issue (2): 437-442.doi: 10.12122/j.issn.1673-4254.2025.02.24

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Latest research progress of rare earth-magnesium alloys in orthopedics

Zhengming SUN1,2(), Kun ZUO3, Xinke ZHU1,2, Hao YUE1,2, Zhengchao GAO1,2   

  1. 1.Department of Orthopedics, Shaanxi Provincial People's Hospital, Xi'an 710068, China
    2.Key Laboratory of Basic and Clinical Transformation of Bone and Joint Diseases in Shaanxi Province, Xi'an 710068, China
    3.Department of Orthopedics, Yangxian Traditional Chinese Medicine Hospital, Yangxian 723300, China
  • Received:2024-12-06 Online:2025-02-20 Published:2025-03-03
  • Supported by:
    Natural Science Foundation for the Youth (NSFY) of China(82101453)

Abstract:

Due to their good properties of elastic modulus, degradability and ability to promote bone repair, magnesium alloys have become a research hotspot in research of orthopedic implants. Nevertheless, most of the biomedical magnesium alloys currently available fail to meet the requirements in orthopedics because of their rapid degradation after implantation. Rare earth-magnesium alloys possess excellent corrosion resistance and are expected to become important materials as clinical orthopedic implants. This review summarizes the recent progress in studies of the physiological functions of rare earth elements, the effects of supplementation of rare earth elements on biomechanical properties and the in vitro and in vivo biocompatibility of magnesium alloys, and their contribution to tendon-bone healing, addressing also the current clinical orthopedic applications of different rare earth-magnesium alloys, challenges, and future strategies for improving these alloys.

Key words: rare earth-magnesium alloys, biocompatibility, corrosion resistance