Gluteal tendinitis and primary coxarthrosis may lead to iliotibial band syndrome: a Mendelian randomization study

doi:10.12122/j.issn.1673-4254.2024.09.23

Abstract

Abstract:

Objective To analyze the causal relationship of gluteal tendinitis and primary coxarthrosis with the occurrence of iliotibial band syndrome using Mendelian randomization. Methods The GWAS data of gluteal tendinitis, primary coxarthrosis and iliotibial band syndrome were screened for high correlation single-nucleotide polymorphisms (SNPs). Mendelian randomization analysis was performed using random-effects inverse variance weighting (IVW), MR-Egger regression, and weighted median method to determine whether gluteal tendinitis and primary coxarthrosis were causally related with iliotibial band syndrome. Heterogeneity test, multiple validity test and sensitivity analysis, and clinical data analysis were used to verify the reliability of the results. Results Both gluteal tendinitis [IVW: OR(95% CI)=1.32 (1.03-1.68), P=0.026] and primary coxarthrosis [IVW:OR (95% CI)=1.40 (1.06-1.84), P=0.017] was positively correlated with iliotibial band syndrome. Conclusion Gluteal tendinitis and primary coxarthrosis may increase the risk of iliotibial band syndrome.

Key words: gluteal tendonitis, primary coxarthrosis, iliotibial band syndrome, Mendelian randomization

Chen YAO, Wenjia LI, Ruiming PANG, Jihong ZHOU. Gluteal tendinitis and primary coxarthrosis may lead to iliotibial band syndrome: a Mendelian randomization study[J]. Journal of Southern Medical University, 2024, 44(9): 1821-1830.

Figures/Tables 13

References 39

1	Renne JW. The iliotibial band friction syndrome[J]. J Bone Jt Surg, 1975, 57(8): 1110-1.
2	朱洺. 髂胫束综合征发病机制和诊疗研究进展[J]. 现代医药卫生, 2022, 38(12): 2068-72.
3	闫君, 邢更彦. 髂胫束综合征临床诊断及其治疗进展[J]. 武警医学, 2023, 34(10): 910-3.
4	Fredericson M, Cookingham CL, Chaudhari AM, et al. Hip abductor weakness in distance runners with iliotibial band syndrome[J]. Clin J Sport Med, 2000, 10(3): 169-75.
5	Ferber R, Noehren B, Hamill J, et al. Competitive female runners with a history of iliotibial band syndrome demonstrate atypical hip and knee kinematics[J]. J Orthop Sports Phys Ther, 2010, 40(2): 52-8.
6	Hemani G, Zheng J, Elsworth B, et al. The MR-Base platform supports systematic causal inference across the human phenome[J]. Elife, 2018, 7: e34408.
7	王世浩, 付赛, 赵宇, 等. 两样本孟德尔随机化研究肾功能对骨质疏松症的因果关系[J]. 现代预防医学, 2022, 49(9): 1537-42, 1589.
8	杨璇, 李岩志, 马伟, 等.基于两样本孟德尔随机化的肺功能与新型冠状病毒肺炎病死风险的因果关系[J].山东大学学报(医学版), 2021, 59(7): 104-11.
9	Yavorska OO, Burgess S. MendelianRandomization: an R package for performing Mendelian randomization analyses using summarized data[J]. Int J Epidemiol, 2017, 46(6): 1734-9.
10	Bowden J, Davey Smith G, Burgess S. Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression[J]. Int J Epidemiol, 2015, 44(2): 512-25.
11	Bowden J, Davey Smith G, Haycock PC, et al. Consistent estimation in Mendelian randomization with some invalid instruments using a weighted Median estimator[J]. Genet Epidemiol, 2016, 40(4): 304-14.
12	Hackinger S, Zeggini E. Statistical methods to detect pleiotropy in human complex traits[J]. Open Biol, 2017, 7(11): 170125.
13	Wagner GP, Zhang JZ. The pleiotropic structure of the genotype-phenotype map: the evolvability of complex organisms[J]. Nat Rev Genet, 2011, 12(3): 204-13.
14	Hadeed A, Tapscott DC. Iliotibial band friction syndrome[M]. Treasure Island (FL): StatPearls Publishing, 2023.
15	Ferber R, Kendall KD, Farr L. Changes in knee biomechanics after a hip-abductor strengthening protocol for runners with patellofemoral pain syndrome[J]. J Athl Train, 2011, 46(2): 142-9.
16	Jensen MP, Chen C, Brugger AM. Interpretation of visual analog scale ratings and change scores: a reanalysis of two clinical trials of postoperative pain[J]. J Pain, 2003, 4(7): 407-14.
17	Dingemans SA, Kleipool SC, Mulders MAM, et al. Normative data for the lower extremity functional scale (LEFS)[J]. Acta Orthop, 2017, 88(4): 422-6.
18	Allison K, Vicenzino B, Wrigley TV, et al. Hip abductor muscle weakness in individuals with gluteal tendinopathy[J]. Med Sci Sports Exerc, 2016, 48(3): 346-52.
19	Woodley SJ, Nicholson HD, Livingstone V, et al. Lateral hip pain: findings from magnetic resonance imaging and clinical examination[J]. J Orthop Sports Phys Ther, 2008, 38(6): 313-28.
20	Bird PA, Oakley SP, Shnier R, et al. Prospective evaluation of magnetic resonance imaging and physical examination findings in patients with greater trochanteric pain syndrome[J]. Arthritis Rheum, 2001, 44(9): 2138-45.
21	Heiderscheit BC. Lower extremity injuries: is it just about hip strength?[J]. J Orthop Sports Phys Ther, 2010, 40(2): 39-41.
22	Moore KL, Dalley AF. Clinically oriented anatomy[M]. 5th ed. Philadelphia, PA: Lippincott Williams &Wilkins, 2005.
23	Murphy NJ, Eyles JP, Hunter DJ. Hip osteoarthritis: etiopathogenesis and implications for management[J]. Adv Ther, 2016, 33(11): 1921-46.
24	Grimaldi A, Mellor R, Hodges P, et al. Gluteal tendinopathy: a review of mechanisms, assessment and management[J]. Sports Med, 2015, 45(8): 1107-19.
25	Grimaldi A, Fearon A. Gluteal tendinopathy: integrating pathomechanics and clinical features in its management[J]. J Orthop Sports Phys Ther, 2015, 45(11): 910-22.
26	Viradia NK, Berger AA, Dahners LE. Relationship between width of greater trochanters and width of iliac wings in tronchanteric bursitis[J]. Am J Orthop, 2011, 40(9): E159-62.
27	Fairclough J, Hayashi K, Toumi H, et al. The functional anatomy of the iliotibial band during flexion and extension of the knee: implications for understanding iliotibial band syndrome[J]. J Anat, 2006, 208(3): 309-16.
28	Bramah C, Preece SJ, Gill N, et al. Is there a pathological gait associated with common soft tissue running injuries[J]? Am J Sports Med, 2018, 46(12): 3023-31.
29	Noehren B, Davis I, Hamill J. ASB clinical biomechanics award winner 2006 prospective study of the biomechanical factors associated with iliotibial band syndrome[J]. Clin Biomech, 2007, 22(9): 951-6.
30	何丹, 涂小华. 下肢肌力训练对髂胫束综合征治疗作用的研究进展[J]. 中国骨伤, 2023, 36(2): 189-93.
31	Tonley JC, Yun SM, Kochevar RJ, et al. Treatment of an individual with piriformis syndrome focusing on hip muscle strengthening and movement reeducation: a case report[J]. J Orthop Sports Phys Ther, 2010, 40(2): 103-11.
32	Wagner T, Behnia N, Ancheta WK, et al. Strengthening and neuromuscular reeducation of the gluteus maximus in a triathlete with exercise-associated cramping of the hamstrings[J]. J Orthop Sports Phys Ther, 2010, 40(2): 112-9.
33	Fredericson M, Weir A. Practical management of iliotibial band friction syndrome in runners[J]. Clin J Sport Med, 2006, 16(3): 261-8.
34	Fredericson M, Wolf C. Iliotibial band syndrome in runners: innovations in treatment[J]. Sports Med, 2005, 35(5): 451-9.
35	Friede MC, Innerhofer G, Fink C, et al. Conservative treatment of iliotibial band syndrome in runners: are we targeting the right goals?[J]. Phys Ther Sport, 2022, 54: 44-52.
36	Bohm S, Mersmann F, Arampatzis A. Human tendon adaptation in response to mechanical loading: a systematic review and meta-analysis of exercise intervention studies on healthy adults[J]. Sports Med Open, 2015, 1(1): 7.
37	Maganaris CN, Chatzistergos P, Reeves ND, et al. Quantification of internal stress-strain fields in human tendon: unraveling the mechanisms that underlie regional tendon adaptations and mal-adaptations to mechanical loading and the effectiveness of therapeutic eccentric exercise[J]. Front Physiol, 2017, 8: 91.
38	Svensson RB, Heinemeier KM, Couppé C, et al. Effect of aging and exercise on the tendon[J]. J Appl Physiol, 2016, 121(6): 1237-46.
39	Friede MC, Klauser A, Fink C, et al. Stiffness of the iliotibial band and associated muscles in runner's knee: assessing the effects of physiotherapy through ultrasound shear wave elastography[J]. Phys Ther Sport, 2020, 45: 126-34.

SNPs	CHR	POS	EA	OA	EAF	BETA	SE	P
rs145759079	6	18249568	C	T	0.044	0.467	0.103	6.07E-06
rs11886188	8	35063675	C	T	0.103	0.330	0.072	5.04E-06
rs1374441	19	148801056	A	G	0.777	-0.259	0.055	2.14E-06
rs73008633	25	5337676	A	G	0.088	0.356	0.077	3.83E-06
rs1511351	34	24195143	A	G	0.978	-0.605	0.135	6.86E-06
rs138650211	45	108684970	C	T	0.020	0.66	0.143	3.91E-06
rs117753069	84	68563665	A	G	0.073	0.367	0.083	9.19E-06
rs149577837	91	81617985	G	A	0.004	1.211	0.261	3.57E-06
rs181995618	148	49814156	A	G	0.014	-1.60	0.320	5.30E-07
rs12595397	153	69339657	T	C	0.729	-0.246	0.052	2.32E-06

SNPs	CHR	POS	EA	OA	EAF	BETA	SE	P
rs145759079	6	18249568	C	T	0.044	0.467	0.103	6.07E-06
rs11886188	8	35063675	C	T	0.103	0.330	0.072	5.04E-06
rs1374441	19	148801056	A	G	0.777	-0.259	0.055	2.14E-06
rs73008633	25	5337676	A	G	0.088	0.356	0.077	3.83E-06
rs1511351	34	24195143	A	G	0.978	-0.605	0.135	6.86E-06
rs138650211	45	108684970	C	T	0.020	0.66	0.143	3.91E-06
rs117753069	84	68563665	A	G	0.073	0.367	0.083	9.19E-06
rs149577837	91	81617985	G	A	0.004	1.211	0.261	3.57E-06
rs181995618	148	49814156	A	G	0.014	-1.60	0.320	5.30E-07
rs12595397	153	69339657	T	C	0.729	-0.246	0.052	2.32E-06

SNPs	CHR	POS	EA	OA	EAF	BETA	SE	P
rs10763007	10	53809803	T	A	0.243	-0.055	0.012	9.40E-06
rs10843013	12	27872263	C	A	0.197	0.105	0.013	6.59E-16
rs10846653	12	124313540	G	A	0.333	0.076	0.011	6.68E-12
				……
rs9485587	6	96048819	G	T	0.195	0.064	0.013	1.24E-06
rs9919834	13	40678828	G	A	0.087	-0.129	0.019	1.99E-11
rs9990056	3	112764617	A	G	0.530	-0.047	0.011	7.40E-06

SNPs	CHR	POS	EA	OA	EAF	BETA	SE	P
rs10763007	10	53809803	T	A	0.243	-0.055	0.012	9.40E-06
rs10843013	12	27872263	C	A	0.197	0.105	0.013	6.59E-16
rs10846653	12	124313540	G	A	0.333	0.076	0.011	6.68E-12
				……
rs9485587	6	96048819	G	T	0.195	0.064	0.013	1.24E-06
rs9919834	13	40678828	G	A	0.087	-0.129	0.019	1.99E-11
rs9990056	3	112764617	A	G	0.530	-0.047	0.011	7.40E-06

Method	nSNP	BETA	SE	OR	95% CI	P
MR-Egger	10	0.289	0.241	1.335	0.83-2.14	0.264
Weighted median	10	0.254	0.166	1.290	0.92-1.80	0.126
Inverse variance weighted	10	0.276	0.124	1.318	1.03-1.68	0.026