Abstract: Objective To summarize the clinical characteristics of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and explore the value of MOG-IgG titers for diagnosis and evaluating disease severity of MOGAD. Methods This retrospective study was conducted among the patients positive for serum MOG- IgG admitted in our hospital from December, 2020 to December, 2022. With 1∶100 as the cutoff value of MOG-IgG titer, the patients were divided into low and high MOG- IgG titer groups for comparison of general demographic data, laboratory test results, imaging features, treatment, and prognosis. Results Of the 36 patients included, 28 were diagnosed with MOGAD (77.78% ), including 15 with low and 13 with high MOG- IgG titers. Compared with the cases reported previously, the MOGAD patients included herein showed a higher prevalence of sensory abnormalities (52.78%) and a lower prevalence of vision loss (25%). Magnetic resonance imaging showed that the periventricular white matter was the most common lesion site (45.71%). The patients with high MOG-IgG titers had significantly lower peripheral blood lymphocyte counts (P=0.025) with an increased neutrophil- to-lymphocyte ratio (P=0.045), higher serum free thyroxine levels (P=0.033) and higher cerebrospinal fluid glucose levels (P=0.007) as compared with those with low MOG- IgG titers. Conclusion Low titers and high titers of MOG- IgG have similar diagnostic value for MOGAD. The serum titers of MOG- IgG are probably associated with the disease severity and stress levels of the patients with MOGAD.

Key words: myelin oligodendrocyte glycoprotein; magnetic resonance imaging; demyelinating disease