Journal of Southern Medical University

Journal of Southern Medical University ›› 2022, Vol. 42 ›› Issue (6): 955-956.doi: 10.12122/j.issn.1673-4254.2022.06.22

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Progress in the study of antiviral activity of cepharanthine against SARS-CoV-2

FAN Huahao, LIU Ke, HONG Bixia, HE Shiting, HAN Pengjun, LI Maochen, WANG Shuqi, TONG Yigang   

  1. College of Life Science and Technology, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China
  • Online:2022-06-20 Published:2022-06-27

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Abstract: As a member of the dibenzyl isoquinoline alkaloid family, cepharathine is an alkaloid from the traditional Chinese medicine cepharathine, which is mainly used for treatment of leukopenia and other diseases. Recent studies of the inhibitory effect of cepharathine against SARS-CoV-2 have attracted widespread attention and aroused heated discussion. As the original discoverer of the anti-SARS-CoV-2 activity of cepharanthine, here we briefly summarize the discovery of cepharanthine and review important progress in relevant studies concerning the discovery and validation of anti-SARS-CoV-2 activity of cepharathine, its antiviral mechanisms and clinical trials of its applications in COVID-19 therapy.

Key words: cepharanthine; SARS-CoV-2; research progress