Abstract: Objective To explore the correlation of triglyceride-glucose product (TyG) index with chronic kidney disease (CKD) in elderly population in Lanzhou (Gansu Province, China). Methods From May to September, 2011, a total of 3868 middle-aged and elderly individuals without CKD from 3 communities in Lanzhou were selected as the cohort study population and were followed for an average of 3.1 years (from June, 2014 to August, 2015). After excluding those with missing follow-up data, a total of 3439 individuals were included for analysis, who were divided according to the quartile of TyG index into Q1 group (TyG≤8.47), Q2 group (TyG 8.48-8.84), Q3 group (TyG 8.85-9.20) and Q4 group (TyG>9.20). The estimated glomerular filtration rate (eGFR) and urinary albumin/creatinine ratio (UACR) were used to evaluate the renal function of the participants. Results In this cohort, a high TyG index was found to correlate with a high risk of CKD (P<0.05). Analysis of the follow-up data showed that the TyG index was significantly higher in patients who developed CKD during the follow-up than in those without CKD (P<0.05). Logistic regression analysis showed that TyG index was an independent risk factor for abnormal eGFR and CKD (P<0.05). Conclusion A high TyG index is an independent risk factor for CKD in middle-aged and elderly population.

Key words: triglyceride-glucose product index; chronic kidney disease; glomerular filtration rate; urine albumin/creatinine