左旋精氨酸对岛状皮瓣缺血再灌注后微循环的影响

南方医科大学学报 ›› 2005, Vol. 25 ›› Issue (07): 871-873.

左旋精氨酸对岛状皮瓣缺血再灌注后微循环的影响

陈静, 庄洪兴, 韩娟, 赵延勇

中国协和医科大学中国医学科学院整形外科医院, 北京, 100041

出版日期:2005-07-20 发布日期:2005-07-20
基金资助:
收稿日期:2004-8-26。
作者简介:陈静(1973- ),男,现为中国协和医科大学在读博士研究生,主治医师,电话:010-88703931,E-mail:Chenjing_168@tom.com

Effects of L-arginine on the microcirculation of rat island skin flaps after ischemia-reperfusion

CHEN Jing, ZHUANG Hong-xin, HAN Juan, ZHAO Yang-yong

中国协和医科大学中国医学科学院整形外科医院, 北京, 100041

Online:2005-07-20 Published:2005-07-20

摘要/Abstract

摘要： 目的研究应用外源性左旋精氨酸提高大鼠岛状皮瓣皮瓣成活率的机制。方法建立SD大鼠腹部岛状皮瓣模型,对侧股动脉插管注射左旋精氨酸后,观测皮瓣微循环血量、局部组织MDA和NO水平及7d后皮瓣成活率等方面的变化。结果与对照组相比较,左旋精氨酸治疗组皮瓣微循环血量增加,组织NO合成增多,MDA水平降低,7d后皮瓣成活率显著提高。结论左旋精氨酸作为NO生成剂,可以通过增加组织NO含量而改善皮瓣微循环,进而减少组织缺血再灌注损伤而提高皮瓣成活率。

Abstract: Objective To investigate the effects of L-arginine on the microcirculation and survival of rat island skin flaps after ischemia-reperfusion. Method A right lower abdominal island flap was created in SD rats and the microcirculatory blood flow in these flaps measured with laser Doppler velocimetry following L-arginine injection via the contralateral femoral artery.Both NO and malondialdehyde (MDA) levels in the flaps were assayed and the survival of the flaps replanted in situ was evaluated 1 week later. Results L-arginine treatment caused increase in the microcirculatory blood flow of the flaps and elevation of NO while and decrease of MDA levels.The survival rate of the flaps with L-arginine treatment was significantly higher than the flaps from saline-treated and normal rats. Conclusion L-arginine can improve the survival of island flap through increasing the microcirculatory blood flow and lessening ischemia-reperfusion injury of the flaps.

中图分类号:

R-33

陈静, 庄洪兴, 韩娟, 赵延勇. 左旋精氨酸对岛状皮瓣缺血再灌注后微循环的影响[J]. 南方医科大学学报, 2005, 25(07): 871-873.

CHEN Jing, ZHUANG Hong-xin, HAN Juan, ZHAO Yang-yong. Effects of L-arginine on the microcirculation of rat island skin flaps after ischemia-reperfusion[J]. Journal of Southern Medical University, 2005, 25(07): 871-873.

参考文献

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