南方医科大学学报

南方医科大学学报 ›› 2005, Vol. 25 ›› Issue (07): 868-870.

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血管性帕金森综合征与帕金森病临床特点及影像学的对比研究

赵德强   

  1. 辽宁省朝阳市第二医院神经科, 辽宁, 朝阳, 122000
  • 出版日期:2005-07-20 发布日期:2005-07-20
  • 基金资助:
    收稿日期:2005-3-18。
    作者简介:赵德强(1968- ),男,本科,在读硕士研究生

Comparative assessment of clinical features and imaging findings for patients with vascular parkinsonism and idiopathic Parkinson’s disease

ZHAO De-qiang   

  1. 辽宁省朝阳市第二医院神经科, 辽宁, 朝阳, 122000
  • Online:2005-07-20 Published:2005-07-20

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摘要： 目的 探讨老年人血管性帕金森综合征(vascular parkinsonism,VP)临床和影像特点,及其与帕金森病(Parkinson’s disease,PD)的区别。方法 对54例VP及53例PD住院老年患者的临床表现及影像学检查结果进行比较分析。结果 临床上VP患者以偏瘫、强直、球麻痹为主要临床表现,锥体束损害表现明显,而静止性震颤少见,PD患者则以震颤-齿轮样强直为主;影像学上VP患者可见明显的影像学异常,主要以腔隙性脑梗死为主,部位可位于单侧、双侧基底节或额叶白质,此外部分病例在大脑脚、侧脑室旁可见缺血性改变。而PD组则未见可见的缺血性改变;抗PD药物治疗的疗效方面,PD组明显优于VP。结论 VP作为一种独立的临床综合征,其临床表现与PD有所不同,其影像学改变也不同于PD;用左旋多巴替代疗法,效果欠佳。

Abstract: Objective To compare the differences of clinical features and imaging findings between vascular parkinsonism (VP) and idiopathic Parkinson’s disease (PD). Method The clinical features and imaging findings from 54 patients with VP and 53 patients with PD were compared. Results The main clinical manifestations of patients with VP were hemiplegia,rigidity and bulbar palsy with obviously pyramidal tract system damage and less rest tremor.Patients with PD showed remar-kable tremor-cogwheel rigidity.In the aspect of imageology,there were obvious imaging changes in patients with VP,mainly manifested lacunar infarction located in unilateral or bilateral basal ganglia and white matter of frontal lobe.Furthermore,some ischemic changes could be seen in the cerebral peduncle and lateral cerebral ventricle.In patients with PD,ischemic changes were invisible.As to the therapeutic effect to the anti-Parkinson’s disease,patients with PD showed better effect than VP patients. Conclusion As a self-sustaining clinical syndrome,the clinical manifestations and imaging findings in patients with VP are different from those with PD.

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