南方医科大学学报

南方医科大学学报 ›› 2018, Vol. 38 ›› Issue (02): 224-.

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FAM135B与赖氨酸乙酰转移酶在维吾尔族食管鳞状细胞癌中的表达

刘江，朱君玲，张亚历，白杨   

  • 出版日期:2018-02-20 发布日期:2018-02-20

Expression pattern of FAM135B and K (lysine) acetyltransferase 5 in esophageal squamous cell carcinoma in Uygur patients

  • Online:2018-02-20 Published:2018-02-20

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摘要： 目的探讨序列相似家族135成员B（FAM135B）与赖氨酸乙酰转移酶（KAT5）在维吾尔族食管鳞状细胞癌（ESCC）中的表 达规律。方法使用罗氏全自动免疫组化仪检测40对维吾尔族ESCC及其癌旁组织中FAM135B与KAT5的表达情况，分析两 种蛋白间表达的相关性及与临床特征的相关性。结果维吾尔族ESCC标本中FAM135B、KAT5 表达分别占92.50%（37/40）、 15.00%（6/40）；癌组织中FAM135B 表达强阳性者所占比例高于癌旁组织［45.00%（18/40）vs 22.50%（9/40），χ 2=4.528，P= 0.033］；癌组织中KAT5 表达阴性者所占比例与癌旁组织差异无统计学意义［85.00%（34/40）vs 87.50%（35/40），χ 2=0.105，P= 0.745］；ESCC 与其配对癌旁组织FAM135B 强阳性表达具有良好正相关性（Kendall 相关系数=0.707，P<0.001）；癌组织的 FAM135B强阳性表达与其KAT5表达具有显著负相关性（Kendall相关系数=-0.946，P<0.001）；FAM135B与KAT5表达与ESCC 患者性别、年龄、肿瘤部位、分化程度、浸润深度、淋巴结转移及临床分期均无明显相关性（P>0.05）。结论FAM135B强阳性表 达可能是维吾尔族ESCC发生的重要分子基础，且该分子可能通过KAT5的负性表达发挥作用。

Abstract: Objective To explore the expression of the family with sequence similarity 135 member B (FAM135B) and K(lysine) acetyltransferase 5 (KAT5) in esophageal squamous cell carcinoma (ESCC) in Uygur patients. Methods The expression of FAM135B and KAT5 in ESCC tissues and paired adjacent tissues from 40 Uygur patients were detected using Roche Benchmark XT. The correlation of FAM135B and KAT5 and their correlation with the clinicopathological characteristics of the patients were analyzed. Results The positivity rates of FAM135B and KAT5 in ESCC tissues were 92.50% (37/40) and 15.00%(6/ 40) in these patients, respectively. The ESCC tissues showed a significantly higher rate of strong FAM135B expression than the adjacent tissues［45.00% (18/40) vs 22.50% (9/40); χ2=4.528, P=0.033］, but the rates of negative KAT5 expression was similar between ESCC and adjacent tissues［85.00% (34/40) vs 87.50% (35/40); χ2=0.105, P=0.745］. Strong expressions of FAM135B in ESCC tissues and the paired adjacent tissues were well correlated (Kendall’s coefficient = 0.707, P<0.001). In ESCC tissues, a strong expression of FAM135B showed a significant negative correlation with KAT5 expression (Kendall’s coefficient=-0.946, P< 0.001). Neither FAM135B nor KAT5 expression was associated with the patients’ gender, age, tumor site, tumor differentiation, invasion, lymph node metastasis and clinical stage (all P>0.05). Conclusion A strong expression of FAM135B may be an important molecular basis for the occurrence of ESCC in Uygur patients and plays its role by negatively regulating the expression of KAT5.