Abstract: Objective To analyze the effectiveness and safety of controlled-release dinoprostone insert for term labor induction in the Pearl River Delta of Guangdong province. Methods Twenty hospitals using controlled-release dinoprostone insert for term labor induction in the Pearl River Delta of Guangdong province were stratified into provincial hospitals and municipal hospitals, and three hospitals of each level were selected as research units. According to the inclusion and exclusion criteria, 1390 pregnant women receiving term labor induction using controlled-release dinoprostone insert were retrospectively analyzed to evaluate the the effectiveness and safety with another 957 pregnant women with induced abortion using oxytocin as the control group. Results Compared with the control group, the controlled-release dinoprostone insert group showed a significantly longer length of the latent phase of labor (4.06 ± 2.65 vs 3.20 ± 2.08 h, P=0.003, 95%CI [0.182, 0.920]) and shorter lengths of the active phase (1.73±1.32 vs 2.22±1.75 h, P=0.000, 95%CI [-0.795, -0.363]) and the second stage of labor (0.49±0.37 vs 0.54±0.43 h, P=0.003, 95%CI [-0.137, -0.028]). No significant differences were found in the length of the first stage of labor, the vaginal delivery rate, adverse reactions, or fetal outcomes between the two groups. Conclusion Controlled-release dinoprostone insert is effective and safe for labor induction at term.