南方医科大学学报

南方医科大学学报 ›› 2016, Vol. 36 ›› Issue (12): 1718-.

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环氧合酶-2和碱性成纤维细胞生长因子在鼻咽癌组织中的表达及与放疗敏感性的相关性

赵建夫，徐萌，陈文慧，赵凤芝，王奕鸣，庄承海   

  • 出版日期:2016-12-20 发布日期:2016-12-20

Expressions of cyclooxygenase-2 and basic fibroblast growth factor in nasopharyngeal carcinoma and their association with radiotherapy sensitivity

  • Online:2016-12-20 Published:2016-12-20

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摘要： 目的探讨环氧合酶-2（COX-2）和碱性成纤维细胞生长因子（bFGF）在鼻咽癌组织中的表达及其与放疗敏感性的相关性。 方法应用免疫组化方法检测97例鼻咽癌患者活检组织放疗前COX-2和bFGF的表达，并分析二者与放疗敏感性的关系。结 果97例鼻咽癌组织COX-2和bFGF阳性表达率分别为71.1%（69/97）和64.9%（63/97）；COX-2的阳性表达与鼻咽癌的T分期和 N分期有显著的相关性（P<0.05），bFGF的阳性表达与鼻咽癌的N分期有显著的相关性（P<0.05）。COX-2在放疗敏感组和放疗 不敏感组的阳性表达率分别为62.8%和92.6%，bFGF在放疗敏感组和放疗不敏感组的阳性表达率分别为57.1%和85.2%，在鼻 咽癌组织中Spearman相关分析发现，COX-2的表达与bFGF的表达呈明显正相关（相关系数r=0.486，P<0.05）；根据COX-2和 bFGF表达情况，把患者分为4 组：COX-2（-）and bFGF（-），COX-2（-）and bFGF（+），COX-2（+）and bFGF（-），and COX-2（+） and bFGF（+）。联合COX-2表达和bFGF表达分析后，发现不同亚组与鼻咽癌的放疗敏感性明显相关（P<0.05）。结论COX-2 和bFGF在鼻咽癌组织中的表达升高，且两者与肿瘤的放疗敏感性明显相关，可作为预测鼻咽癌放疗敏感性的重要指标。

Abstract: Objective To detect the expressions of cyclooxygenase-2 (COX-2) and basic fibroblast growth factor (bFGF) and evaluate their value in predicting the radiotherapy sensitivity in nasopharyngeal carcinoma (NPC). Methods The expressions of COX-2 and bFGF were detected immunohistochemically in biopsy samples of NPC, and their relationship with the radiotherapy sensitivity of the tumors were analyzed. Results In 97 NPC cases, the positivity rates of COX-2 and bFGF were 71.1% (69/97) and 64.9% (63/97), respectively. Correlation analysis demonstrated that a positive COX-2 expression was positively correlated with an advanced T status and N status, and bFGF expression was positively associated with an advanced N status in NPCs. In radiotherapy-sensitive and radiotherapy-insensitive cases, the positive rate of COX-2 was 62.8% and 92.6%, and that of bFGF was 57.1% and 85.2%, respectively. The expression of COX-2 was positively correlated with that of bFGF (r=0.486, P<0.05). The radiotherapy sensitivity differed significantly among patients with different statuses of COX-2 and bFGF positivity. Conclusion COX-2 and bFGF can be effective and sensitive biomarkers for predicting radiotherapy sensitivity in NPC.