南方医科大学学报 ›› 2016, Vol. 36 ›› Issue (08): 1157-.

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非哺乳期乳腺炎患者血液中自身抗体和免疫指标的变化及其临床意义

许锐,郭倩倩,杨乐平,赖米林,佟琳   

  • 出版日期:2016-08-20 发布日期:2016-08-20

Variations of peripheral blood autoantibody, immunoglobuliln, and complement levels in patients with non-lactational mastitis and their clinical significances

  • Online:2016-08-20 Published:2016-08-20

摘要: 目的检测非哺乳期乳腺炎患者外周血中自身抗体(ANA、AHA)、免疫球蛋白、补体水平的情况,以探讨非哺乳期乳腺炎 是否是存在免疫功能紊乱的自身免疫性疾病。方法收集2013年9月~2015年5月期间在广东省中医院乳腺科住院治疗的非哺 乳期乳腺炎患者78例,同时选择88例健康人群作为正常对照组,检测其外周血中自身抗体(ANA、AHA)水平、同时检测外周血 免疫球蛋白(IgA、IgM、IgG)及补体(C3、C4、总补体)情况。采用SPSS18.0软件包进行数据处理,采用t检验比较两组免疫指标 的变化,自身抗体的比较采用卡方检验。结果非哺乳期乳腺炎组抗核抗体(ANA)阳性的有50例,占64.10%(50/78),其中荧光 模式以颗粒型和胞浆颗粒型为主,与正常对照组比较有统计学意义(P<0.000)。非哺乳期乳腺炎组抗组蛋白抗体(AHA)阳性的 有28例,占36.00%(28/78),与正常对照组比较有统计学意义(P<0.000)。非哺乳期乳腺炎组IgA、IgM因子,C4、总补体升高,与 正常对照组比较有统计学意义(P<0.05)。结论非哺乳期乳腺炎患者血液中免疫球蛋白及补体水平异常,患者外周血自身抗体 ANA、AHA阳性率高,揭示非哺乳期乳腺炎是一种存在免疫功能紊乱的自身免疫性疾病。

Abstract: Objective To detect the variations in peripheral blood levels of autoantibodies, immunoglobulilns and complements in patients with non-lactational mastitis and investigate whether non-lactational mastitis is an autoimmune disease with immune dysfunction. Methods Seven-eight patients with non-lactational mastitis treated in our hospital between September 2013 and May 2015 and 88 healthy women (control) were examined for peripheral blood levels of antinuclear antibody (ANA), anti-histone antibody (AHA), immunoglobulins (IgA, IgM, and IgG) and complements (C3, C4, and total complements). Results Of the 78 patients with non-lactational mastitis, 50 (64.10%) were positive of ANA showing mainly the granular and cytoplasmic granular fluorescence patterns, and the positivity rate was significantly higher than that in the control group (P< 0.000). Twenty-eight (36.00%) of the patients were positive of AHA, a rate significantly higher than that in the control group (P< 0.000). The levels of IgA, IgM, C4, and total complements levels were all significantly elevated in the patients compared with those in the control group (P<0.05). Conclusion Patients with non-lactational mastitis have abnormal changes in peripheral blood levels of immunoglobulins and complements with high positivity rates for ANA and AHA, indicating that non-lactational mastitis is an autoimmune disease with immune dysfunction.