南方医科大学学报

南方医科大学学报 ›› 2016, Vol. 36 ›› Issue (06): 863-.

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子宫内膜癌组织中DAPK3和c-Myc的表达及其与患者预后的关系

陈晨，郭遂群   

  • 出版日期:2016-06-20 发布日期:2016-06-20

Expressions of DAPK3 and c-Myc in endometrial cancer and their relationship with the patients’ prognosis

  • Online:2016-06-20 Published:2016-06-20

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摘要： 目的探讨子宫内膜癌组织中DAPK3和c-Myc的表达情况、相互关系及其对患者预后的影响。方法运用免疫组织化学 SP法检测132例子宫内膜癌组织中DAPK3和c-Myc的表达，分析DAPK3、c-Myc蛋白的表达与子宫内膜癌临床病理参数的关 系及对子宫内膜癌预后的影响。结果（1）132例组织标本中DAPK3低表达80例（80/132，60.61%），c-Myc高表达71例（71/132， 53.79%）；（2）DAPK3的表达在子宫内膜癌不同FIGO分级（P=0.034），组织学分级（P=0.027），淋巴结转移状态（P=0.022）和肌层 浸润程度（P=0.011）中差异显著；c-Myc的表达在子宫内膜癌不同FIGO分级（P=0.015）和淋巴结转移状态（P=0.031）中差异显 著；（3）生存曲线分析显示，DAPK3低表达患者的生存时间少于高表达患者（P=0.023），而c-Myc高表达患者的生存时间少于低 表达患者（P=0.002）；（4）等级相关分析显示DAPK3和c-Myc在子宫内膜癌中的表达显著负相关（r=-0.310, P<0.001）；（5）COX 回归分析提示，c-Myc高表达是子宫内膜癌患者预后的独立影响因素（P=0.007）。结论DAPK3低表达和c-Myc高表达与子宫 内膜癌的生长浸润行为相关，且与患者预后密切相关。通过检测DAPK3和c-Myc的表达能够更加有效地评估子宫内膜癌患者 的预后。

Abstract: Objective To investigate the expressions of DAPK3 and c-Myc and their prognostic value in endometrial carcinoma (EC). Methods The expressions of DAPK3 and c-Myc were detected immunohistochemically in 132 surgical specimens. The relationship between DAPK3 and c-Myc protein expressions and the clinicopathological features of the patients was evaluated. Results Immunohistochemical analysis revealed low DAPK3 expression in 60.61% (80/132) and high c-Myc expression in 53.79% (71/132) of the specimens of EC. Both DAPK3 expression and c-Myc expression were significantly correlated with FIGO stage (P=0.034 and 0.015, respectively) and lymph node metastasis (P=0.022 and 0.031, respectively). DAPK3 expression was closely correlated with the histological grade (P=0.027) and depth of myometrial invasion (P=0.011). Kaplan-Meier survival analysis indicated that patients with low DAPK3 expressions had a shorter overall survival rate than those with high DAPK3 expressions (P=0.023), while patients with high c-Myc expressions had poorer prognoses than those with low c-Myc expressions (P=0.002). Spearman correlation analysis showed that DAPK3 and c-Myc expressions were negatively correlated (P<0.001, r=−0.310). Multivariate analysis identified a high c-Myc expression as the independent predictor of the prognosis of EC (P=0.007). Conclusions A low expression of DAPK3 and a high expression of c-Myc are associated with aggressive and metastatic behaviors of EC, and their detection may help to predict the prognosis of the EC patients.