南方医科大学学报

南方医科大学学报 ›› 2015, Vol. 35 ›› Issue (07): 1055-.

• • 上一篇    下一篇

血清胱抑素C与血压水平的关系：912例报告

陈海霞，王铁兵，杨邱，唐曙明   

  • 出版日期:2015-07-20 发布日期:2015-07-20

Correlation of serum cystatin C with blood pressure: a cross-sectional study of 912 subjects

  • Online:2015-07-20 Published:2015-07-20

HTML

PDF

872

摘要： 目的探讨血清胱抑素C（Cys C）与血压水平的关系。方法采用横断面研究方法, 从体检人群中随机抽查912例作为研究
对象，通过问卷调查及查询体检结果获取一般资料，运用Pearson和多元逐步回归分析血清Cys C与血压水平的关系。结果血
清Cys C水平在正常血压组、高血压前期组及高血压组三组间比较，差别具有统计学差异（P<0.05）；Pearson 相关分析显示：无论
性别，血清Cys C水平与收缩压（SBP）、舒张压（DBP）、平均动脉压（MAP）、体重指数（BMI）、总胆固醇（TC）、甘油三酯（TG）、低
密度脂蛋白胆固醇（LDL-C）、尿酸（UA）、尿素（BUN）正相关（P<0.05）；以MAP、SBP及DBP为因变量，以血压水平影响因素为
自变量的多元逐步回归分析中结果显示：血清Cys C对SBP和MAP影响最大（P<0.05），对DBP影响不显著（P>0.05）。结论血
清Cys C水平对SBP和MAP的影响显著，可以作为预警高血压病的生物标志物。

Abstract: Objective To study the association between serum cystatin C level and blood pressure. Methods We conducted a
cross-sectional study of 912 subjects randomly sampled from a cohort visiting for routine physical examinations. The
epidemiological data were obtained using questionnaires and from the database of physical examination results. Pearson
analysis and multiple stepwise regression analysis were used to analyze the relationship between blood pressure and cystatin
C. Results The levels of serum cystatin C differed significantly among the normotensive, prehypertensive, and hypertensive
subjects (P<0.05). Pearson analysis revealed that regardless of gender, serum cystatin C was positively correlated with SBP,
DBP, MAP, BMI, TC, TG, LDL-C, UA and BUN (P<0.05). With MAP, SBP and DBP as dependent variables, multiple stepwise
regression analysis of the factors affecting blood pressure indicated that cystatin C had the strongest effect on SBP and MAP
(P<0.05) but did not significantly affect DBP (P>0.05). Conclusion Serum cystatin C level is significantly correlated with SBP
and MAP and can be used as a biomarker for alert of hypertension.