南方医科大学学报

南方医科大学学报 ›› 2015, Vol. 35 ›› Issue (01): 146-.

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糖尿病患者脑钠肽前体水平与心率变异性的相关性

林茴，陈小欢，吴志华，张东辉，陈晓燕   

  • 出版日期:2015-01-20 发布日期:2015-01-20

Association of pro-B-type natriuretic peptide levels with heart rate variability in diabetic
patients

  • Online:2015-01-20 Published:2015-01-20

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摘要： 目的探讨糖尿病患者脑钠肽前体水平（NT-proBNP）和心率变异性（HRV）的相关性。方法对58 例糖尿病患者均进行
HRV分析与NT-proBNP测定，按HRV结果分为HRV异常组和HRV正常组，比较两组的时域和频域指标以及NT-proBNP水平，
并将所有患者的HRV指标与NT-proBNP进行相关性分析。结果HRV异常组NT-proBNP水平（320.2±88.3 pg/ml）与HRV正
常组（80.4±25.2 pg/ml）比较，显著增高（P<0.01），NT-proBNP 与SDNN、三角指数、低频功率、极低频功率负相关（r=-0.55, P<
0.05; r=-0.52, P<0.05; r=-0.62, P<0.01; r=-0.56，P<0.05）。结论糖尿病患者NT-proBNP 水平与HRV相关，NT-proBNP 升高提
示糖尿病的心脏自主神经病变。

Abstract: Objective To investigate the correlation between pro-B-type natriuretic peptide (NT-proBNP) and heart rate
variability (HRV) in patients with diabetes. Methods HRV and NT-proBNP levels were assessed in 58 patients with diabetes.
The time domain and frequency domain indices and the level of NT-proBNP were compared between patients with normal
and abnormal HRV, and the correlation of HRV index and NT-proBNP was analyzed. Results The NT-proBNP level was
significantly higher in patients with abnormal HRV than in those with normal HRV (320.2±88.3 vs 80.4±25.2 pg/ml, P<0.01).
The level of NT-proBNP was negatively correlated with SDNN (r=-0.55, P<0.05), triangle index (r=-0.52, P<0.05), LF (r=-0.62, P<
0.01), and VLF (r=-0.56, P<0.05). Conclusion NT-proBNP level is correlated with HRV, and an increased NT-proBNP indicates
cardiac autonomic neuropathy in diabetic patients.