南方医科大学学报

南方医科大学学报 ›› 2014, Vol. 34 ›› Issue (12): 1776-.

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Mus81基因在中国汉族结直肠癌中的表达及其临床意义

吴帆，陈为佳，谭国钳，刘建伟   

  • 出版日期:2014-12-20 发布日期:2014-12-20

Expression of Mus81 gene in Chinese Han patients with colorectal cancer and its clinical
significance

  • Online:2014-12-20 Published:2014-12-20

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摘要： 目的了解Mus81基因在中国汉族结直肠癌中的表达水平并分析其临床意义。方法收集43例手术切除的中国汉族结直
肠癌及相应的癌旁组织标本，采用巢式荧光定量PCR技术检测标本中Mus81基因的表达水平，并分析Mus81基因表达与结直
肠癌临床病理特征及常规肿瘤指标的相关性。结果Mus81基因在结直肠癌中的表达水平低于相应的癌旁组织（114.6±68.0 vs
202.5±109.0，P<0.001）。Mus81 基因在74.4%（32/43）的病例中表现为表达下调，且其表达下调与结直肠癌的远处转移（P=
0.043）、TNM分期（P=0.022）及P53蛋白高表达（P=0.011）密切相关。结论Mus81基因的表达水平在中国汉族结直肠癌中明显
下调，且其表达下调与结直肠癌的转移潜能及进展相关，提示Mus81是中国汉族结直肠癌的一个潜在分子指标物。

Abstract: Objective To explore the expression pattern of Mus81 gene in Chinese Han patients with colorectal cancer and
analyze its correlation with the clinicopathological parameters and the tumor markers. Methods Mus81 expression was
detected using nested quantitative real-time PCR in the colorectal cancer tissues and corresponding adjacent normal tissues
from 43 Chinese Han patients. The correlations of Mus81 expression profile with the clinicopathological parameters and
common tumor markers were evaluated. Results Mus81 expression level was significantly lower in the colorectal cancer
tissues than in the corresponding adjacent normal tissues (114.6±68.0 vs 202.5±109.0, P<0.001). Of the 43 patients, 32 (74.4%)
showed down-regulated Mus81 expression, which correlated significantly with distant metastasis (P=0.043), high TNM stage
(P=0.022) and high P53 protein expression (P=0.011) of the tumor. Conclusion Down-regulation of Mus81 in colorectal cancer
is correlated with tumor metastasis and progression, suggesting the value of Mus81 as a potential marker for colorectal cancer
in Chinese Han pateints.