南方医科大学学报

南方医科大学学报 ›› 2014, Vol. 34 ›› Issue (09): 1329-.

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多囊卵巢综合征患者反复种植失败后成功妊娠3例及其文献复习

易思思，陈薪，刘玉东，叶德盛，陈士岭   

  • 出版日期:2014-09-20 发布日期:2014-09-20

Successful pregnancy following repeated implantation failure in patients with polycystic
ovary syndrome: report of three cases

  • Online:2014-09-20 Published:2014-09-20

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摘要： 目的探讨体外受精胚胎移植中多囊卵巢综合征（polycystic ovary syndrome, PCOS）患者反复种植失败（38个移植周期）
后获得妊娠分娩的因素，以期对临床提供诊疗参考。方法报告3例多囊卵巢综合症性不孕的患者，在我中心进行多次胚胎移植
的临床处理及结局。对这3个病例的临床资料、特点及处理进行分析总结。结果3例患者经过多次促性腺激素释放激素拮抗
剂（GnRH-ant）方案促排卵及促性腺激素释放激素激动剂（GnRHa）诱发排卵，胚胎移植周期9次获得妊娠和分娩。结论对于卵
巢高反应的反复种植失败的多囊卵巢综合征患者，采用促性腺激素释放激素激动剂（GnRHa）拮抗剂方案促排卵及GnRHa诱发
排卵的方案，寻找和治疗影响胚胎着床的因素，能有效预防卵巢过度刺激征（OHSS）的出现，并取得良好的临床结局。

Abstract: We report 3 cases of polycystic ovary syndrome (PCOS) in which the patients had successful pregnancy after
repeated implantation failure in at least 8 in vitro fertilization and embryo transfer (IVF-ET) cycles. The patients were treated
with gonadotropin-releasing hormone antagonist (GnRH-ant) protocol and gonadotropin-releasing hormone angonist
(GnRHa) for triggering ovulation, and successful pregnancy and normal deliveries were achieved after 9 IVT-ET cycles. For
young patients with PCOS but a good ovarian reserve and a high ovarian response, treatment with GnRH antagonist protocol
and GnRHa alone with appropriate management of the factors that may affect implantation can prevent severe ovarian
hyperstimulation syndrome to achieve favorable clinical outcomes.