南方医科大学学报

南方医科大学学报 ›› 2014, Vol. 34 ›› Issue (07): 1016-.

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乳腺真空辅助旋切系统活检后乳腺癌患者针道转移的几率

任重阳，廖宁，张国淳，安胜利，温灵珠，钱学珂，吕海通   

  • 出版日期:2014-07-20 发布日期:2014-07-20

Implantation metastasis of breast cancer in vacuum-assisted breast biopsy needle tract
and the impact of neoadjuvant chemotherapy

  • Online:2014-07-20 Published:2014-07-20

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摘要： 目的研究中国人群乳腺癌患者发生真空辅助旋切系统活检（VABB）针道种植转移的几率及新辅助化疗对其产生的影
响。方法将通过VABB诊断为乳腺癌的病人分为两组，一组直接进行外科开放性手术（直接手术组），一组先进行新辅助化疗
后再进行外科开放性手术（新辅助化疗组）。分析两组病人发生针道种植转移的几率，以及两组病人的无病生存（DFS）和总生
存（OS），并采用相应的统计学方法进行两组间的比较。结果共有214名患者入组，其中直接手术组94名，新辅助化疗组120
名，中位随访时间为29.2月，两组发生针道转移的几率分别为3.2%和0.8%，两者相比无显著性差异（P=0.206，χ2检验）；DFS和
OS亦无显著差异（DFS P=0.221，OS P=0.531，Log-rank检验）。结论经VABB后两组乳腺癌患者的针道种植转移率低，新辅助
化疗不会导致VABB后的针道种植转移率的增加。

Abstract: Objective To study the incidence of implantation metastasis of breast cancer in vacuum-assisted breast biopsy
(VABB) needle tract in Chinese patients and evaluate the effect of neoadjuvant chemotherapy on needle tract metastasis
following VABB. Methods The breast cancer patients with established diagnosis by VABB were divided into two groups to
receive open surgery or neoadjuvant chemotherapy prior to open surgery. The incidence of needle tract metastasis, disease-free
survival (DFS) and overall survival (OS) were compared between the two groups. Results A total of 214 patients were enrolled,
among whom 94 directly underwent surgeries and 120 had neoadjuvant chemotherapy before surgery. The two groups
showed no significant differences in the incidence of needle tract metastasis (3.2% vs 0.8%, P=0.206), DFS (P=0.221), or OS (P=
0.531). Conclusion The incidence of needle tract metastasis is low after VABB, and neoadjuvant chemotherapy does not
increase this risk.