南方医科大学学报

南方医科大学学报 ›› 2014, Vol. 34 ›› Issue (06): 913-.

• • 上一篇    

Wnt/β-catenin信号通路在肝细胞癌中的促进作用

谢亮海，蒋晗，吴福生   

  • 出版日期:2014-06-20 发布日期:2014-06-20

Role of Wnt/β-catenin signaling pathway in promoting tumorigenesis of hepatocellular
carcinoma

  • Online:2014-06-20 Published:2014-06-20

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摘要： Wnt/β-catenin 信号通路与肿瘤有着密切的关系，此通路的异常活化参与人类多种癌症的发病过程。肝细胞癌
（hepatocellular carcinoma, HCC）在全球肿瘤中死亡率位居第3，但其发生发展的分子机制仍不清楚。目前，研究表明Wnt/
β-catenin信号通路及其他相互作用信号通路，以及乙型肝炎病毒、丙型肝炎病毒相互作用蛋白等共同在HCC的发生发展过程
中起着关键作用，因而，揭示该信号通路在HCC中的作用可为其早期诊断、治疗以及预后提供理论基础。现对Wnt/β-catenin信
号通路在HCC中的作用及目前研究状况作一简要综述。

Abstract: Wnt/β-catenin signaling pathway has a close relationship with cancer and is abnormally activated in many human
cancers. Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death worldwide, but the
molecular mechanisms of HCC are still poorly understood. Current studies indicate that Wnt/β-catenin signaling pathway
plays a key role in the development and progression of HCC. Validating the role and mechanism of Wnt/β-catenin signaling
pathway in HCC will provide a theoretical basis for early diagnosis and treatment of HCC. In this review, we summarize the
role of Wnt/β-catenin signaling pathway in HCC and the progress of current researches.