南方医科大学学报

南方医科大学学报 ›› 2014, Vol. 34 ›› Issue (05): 740-.

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定量参数应变均值在判定肝纤维化程度的应用

周立峰，丛淑珍，裴书芳，陈越峰，周瑞莉   

  • 出版日期:2014-05-20 发布日期:2014-05-20

Value of strain means of quantitative parameters in diagnosis of liver fibrosis

  • Online:2014-05-20 Published:2014-05-20

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摘要： 目的探讨组织弥散定量分析参数应变均值在判定肝纤维化程度上的价值。方法慢性乙型肝炎患者130例，肝穿前均行
组织弥散定量参数分析，分析参数应变均值在不同程度肝纤维化上的表现。所有病例均经病理证实。结果肝纤维化不同病理
分期应变均值之间的差异均具有统计学意义。运用ROC曲线界定应变均值在判定S≥1、S≥2、S≥3 和S=4上的诊断界点分别约
为：116.2、111.4、101.6、97.5，其诊断敏感性分别为91.2%、90.8%、95.8%和89.7%；特异性分别为90.4%、98.6%、93.8%和95.6%；
准确度分别为90.6%、94.7%、95.5%和91.8%。结论组织弥散定量参数应变均值在判定肝纤维化不同程度上能够给出具体数
值，具有较好的价值。

Abstract: Objective To explore the value of the strain means of the quantitative parameters of organization diffusion in
determining the degree of liver fibrosis. Methods A total of 130 patients with chronic hepatitis B were examined for
quantitative analysis of organization diffusion before liver biopsy to analyze the performance of the strain means in liver
fibrosis of different degrees. All the cases were confirmed by pathology. Results The strain means differed significantly
between different stages of liver fibrosis. Using the best cut-off values of 116.2, 111.4, 101.6 and 97.5 for diagnosis of S≥1, S≥2,
S≥3 and S=4, the diagnostic sensitivities were 91.2%, 90.8%, 95.8% and 89.7%, with specificities of 90.4%, 98.6%, 93.8% and
95.6% and accuracies of 90.6% , 94.7% , 95.5% and 91.8% , respectively. Conclusion The strain mean can provide specific
numerical indicators to determine the degree of liver fibrosis.