南方医科大学学报

南方医科大学学报 ›› 2014, Vol. 34 ›› Issue (03): 423-.

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MMP2过表达在子宫内膜腺癌的临床意义

李姝君，沈湘，杨志雄，吴爱兵，唐志，黎明春，宁映霞   

  • 出版日期:2014-03-20 发布日期:2014-03-20

Clinical significance of MMP2 overexpression in endometrial adenocarcinoma

  • Online:2014-03-20 Published:2014-03-20

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摘要： 目的探讨MMP2 表达与子宫内膜腺癌临床参数和预后之间相关性。方法我们收集了81 例子宫内膜腺癌患者石蜡标
本。这些患者的年龄在32~80岁之间。随后，利用免疫组化SP方法检测了81例子宫内膜腺癌中MMP2表达情况。最后，我们
使用SPSS软件统计分析了MMP2表达与与子宫内膜腺癌进展和预后之间相关性。结果MMP2在子宫内膜腺癌胞浆中表达。
此外，过表达的MMP2与子宫内膜腺癌分化程度（P=0.015）以及预后（P=0.041）呈负性相关。结论MMP2过表达是子宫内膜腺
癌患者的一个恶性标志物。

Abstract: Objective To explore the expression of MMP2 and its correlation with the clinical features and prognosis of
endometrial adenocarcinoma. Methods We collected paraffin-embedded samples from 81 patients with endometrial
adenocarcinoma aged 32 to 80 years to examine the expression of MMP2 using immunohistochemistry. The correlation of
MMP2 expression with the clinical characteristics and prognosis of the patients was analyzed. Results MMP2 protein was
expressed in the cytoplasm of the tumor cells. MMP2 over-expression was negatively correlated with tumor differentiation (P=
0.015) and prognosis (P=0.041) of endometrial adenocarcinoma. Conclusion MMP2 over-expression is a potential malignant
biomarker in endometrial adenocarcinoma.