南方医科大学学报

南方医科大学学报 ›› 2014, Vol. 34 ›› Issue (03): 419-.

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IgA肾病患者血清6种常见过敏食物特异性抗体的检测

周朝敏，刘志刚，眭维国，谷东风，李永强，邹和群   

  • 出版日期:2014-03-20 发布日期:2014-03-20

Detection of serum food specific antibodies of 6 common foods in patients with IgA
nephropathy

  • Online:2014-03-20 Published:2014-03-20

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摘要： 目的初步探讨6种常见过敏食物的主要过敏蛋白与IgA肾病发病的关系。方法采用ELISA双抗体夹心法检测并比较
31例IgA肾病患者及80例健康体检者血清中6种常见过敏食物的主要过敏蛋白特异性的IgA1、IgG及IgE水平，并对所有病人
进行食物过敏情况问卷调查，观察多种食物抗体水平均明显升高的患者的临床特征。结果IgA肾病组患者血清中6种常见过
敏食物的主要过敏蛋白特异性的IgA1及IgG水平均显著高于健康对照组（P<0.05）。两组中均未检测到食物特异性的IgE。所
有病人均无明确的食物过敏史。多种食物（大于4种）特异性IgG抗体水平均明显升高的患者均有蛋白尿。结论某些食物尤其
是高致敏性食物在IgA肾病的发病及进程中可能伴有重要角色。

Abstract: Objective To explore the relationship between the major allergens of 6 common allergic foods and IgA nephropathy.
Methods A sensitive sandwich enzyme-linked immunosorbent assay (ELISA) was used to detect the serum levels of
food-specific IgA1, IgG and IgE in 31 patients with IgA nephropathy and 80 healthy volunteers. All the patients were
examined for a history of food allergy using a questionnaire. Results Serum levels of IgA1 and IgG against the major allergens
of the 6 common allergic foods were significantly higher in patients with IgA nephropathy than in healthy volunteers (P<0.05).
There was no detectable food-specific IgE antibodies in the two groups. No patients had a clear history of food allergy. All the
patients with increased IgG levels specific to 4 or more foods simultaneously had proteinuria. Conclusion Some foods
especially the highly allergic ones may participate in the pathogenesis and progression of IgA nephropathy.