南方医科大学学报

南方医科大学学报 ›› 2014, Vol. 34 ›› Issue (01): 128-.

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前列腺凋亡应答蛋白4促凋亡和肿瘤特异性抑制作用的研究进展

吴增丁，王冠林，张宽仁   

  • 出版日期:2014-01-20 发布日期:2014-01-20

Pro-apoptosis and selective anticancer activities of prostate apoptosis response protein 4:
research progress and prospects

  • Online:2014-01-20 Published:2014-01-20

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摘要： 前列腺凋亡应答蛋白4（Par-4）作为促凋亡因子，最先在雄性激素不依赖型前列腺癌细胞（AT-3）中发现。内源性Par-4使癌
细胞对凋亡刺激更敏感化，但是外源性Par-4可选择性地直接导致癌细胞凋亡，并通过基因突变实验发现该活性依赖于它的核
心结构域SAC。Par-4和SAC可特异性地导致癌细胞凋亡，因此是潜在的癌症靶点治疗药物。本文综述了Par-4的发现、结构、
功能及其在细胞内信号通路，最后讨论了Par-4和SAC在癌症临床治疗中的应用前景以及在基础研究和临床应用中存在的问题。

Abstract: As a pro-apoptotic factor, prostate apoptosis response protein 4 (par-4) was first found in the male
hormone-dependent prostate cells (AT-3). Endogenous Par-4 sensitizes cancer cells to apoptotic stimuli, but exogenous Par-4
selectively induces apoptosis in cancer cells, and these activities depends on the structure of its core domain SAC. Par-4 and
SAC can specifically induce apoptosis of cancer cells but not of normal cells, and are therefore potential anti-cancer drugs. In
this review we summarize the discovery, structure, and function of par-4, and its intracellular signaling pathways, then discuss
the application prospects of Par-4 and SAC in the clinical treatment of cancer and the problems in its research and clinical
applications .