南方医科大学学报 ›› 2013, Vol. 33 ›› Issue (12): 1839-.
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张玉明
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摘要: 脐血为需要接受异基因造血干细胞移植的患者提供了一种可供选择的干细胞来源。自第1例脐血移植治疗范可尼贫血患儿获得成功以来,全球范围内脐血移植呈指数增长,在儿童恶性血液病及某些先天性代谢病的治疗方面取得了长足的进展。然而由于采集的脐血量有限、输注的脐血中所含的造血干细胞较少,长期以来脐血移植只用于儿童,因而限制了其在成人患者的应用。近年来,随着一系列新的移植技术应用于造血干细胞移植领域,成人脐血的治疗效果已得到了改善。本文就脐血移植的最新技术进行综述。
Abstract: Umbilical cord blood is an alternative hematopoietic stem cell source for treatment of hematological diseases that canbe cured by allogeneic hematopoietic stem cell transplantation. Since the first case of umbilical cord blood transplantationperformed successfully in a child with Fanconi anemia, the field of umbilical cord blood transplantation has grownexponentially, and a great progress has been made worldwide in the treatment of children with malignant hematologicaldiseases, including some congenital metabolic disorders. Umbilical cord blood transplantation was initially intended only inthe treatment of pediatric patients, given the small volume collected and the low hematopoietic stem cell dose infused. Inrecent years, the application of new techniques for hematopoietic stem cell transplantation has greatly improved the outcomesof umbilical cord blood transplantation in adult patients. In this review article, we summarize the latest techniques forumbilical cord blood transplantation.
张玉明. 脐血移植新技术进展[J]. 南方医科大学学报, 2013, 33(12): 1839-.
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