南方医科大学学报

南方医科大学学报 ›› 2013, Vol. 33 ›› Issue (12): 1811-.

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CDK6 在鼻咽癌中的表达及临床意义

罗小鹏，覃继新，黄永秩，刘津，王莹，王怀飞，陈家军   

  • 出版日期:2013-12-20 发布日期:2013-12-20

Expression of CDK6 in nasopharyngeal carcinoma and its clinical significance

  • Online:2013-12-20 Published:2013-12-20

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摘要： 目的探讨CDK6在鼻咽癌中的表达及临床意义。方法利用免疫组化检测CDK6在鼻咽以及鼻咽癌组织中表达，并利用
统计学方法分析CDK6在鼻咽与鼻咽癌中表达差异。利用统计学方法分析CDK6与鼻咽癌患者临床参数之间的相关性。结果
分析了101例鼻咽癌组织和30例鼻咽组织中CDK6表达。免疫组化结果显示，CDK6是一个核浆共表达因子。在鼻咽组织中，
CDK6主要在胞浆表达。而在鼻咽癌组织中，主要为核浆共表达。与非癌鼻咽组织相比，CDK6 蛋白在鼻咽癌组织中表达明显
上调（P=0.009）。此外，CDK6调的表达与鼻咽癌组织大小（P=0.020）及临床分期（P=0.039）呈明显的正相关。CDK6表达越高，
患者肿瘤越大，临床分期越晚。结论CDK6表达下调作为不利因素促进了鼻咽癌的发生发展。

Abstract: Objective To explore the expression of CDK6 in nasopharyngeal carcinoma (NPC) and explore its clinical
significance. Methods Immunohistochemistry was used to examine the differential expression of CDK6 protein in 101 NPC
and 30 nasopharyngeal tissues, and the correlation of CDK6 expression with the clinical characteristics was analyzed in NPC
cases. Results Immunohistochemistry demonstrated that CDK6 protein was a co-expressed factor in the cytoplasm and cell
nuclei. CDK6 was expressed predominantly in the cytoplasm in nasopharyngeal tissues, but in NPC tissues, CDK6 was
co-expressed predominantly in the cytoplasm and nuclei. Compared to the nasopharyngeal tissues, NPC tissues showed
significantly up-regulated CDK6 expression (P=0.009) in positive correlation with tumor size (P=0.020) and clinical stages (P=
0.0039). Conclusion Increased CDK6 protein expression is an unfavorable factor that promotes the development and
progression of NPC.