南方医科大学学报

南方医科大学学报 ›› 2013, Vol. 33 ›› Issue (10): 1533-.

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光学相干断层扫描及超声生物显微镜测量眼前房深度的meta分析

陈林江，熊柯，吴京   

  • 出版日期:2013-10-20 发布日期:2013-10-20

Comparison of anterior chamber depth measured by anterior segment optical coherence tomography and ultrasound biomicroscopy: a meta-analysis

  • Online:2013-10-20 Published:2013-10-20

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摘要： 目的比较前节光学相干断层扫描（AS-OCT）及超生物显微镜（UBM）所测量眼前房深度结果的差异程度。方法计算机
检索相关数据库，搜集关于AS-OCT及UBM测量眼前房深度比较的研究性文献，两名评价员按照纳入排除标准独立对文献进
行筛选及质量评价，对最终纳入的文献进行Meta 分析。结果共纳入8 篇研究文献，合计710 眼，Meta 分析显示：AS-OCT及
UBM在全体人群中测得的前房深度值无统计学意义上的差异［SMD=0.19，95%置信区间为（0.00，0.39）］；在原发性闭角型青光
眼患者中测得的前房深度值亦无统计学意义上的差异［SMD=0.02，95%置信区间为（-0.04，0.19）］。结论AS-OCT及UBM所测
量的前房深度不存在显著统计学差异，但由于研究文献偏少、样本量较小，致使本系统评价结果论证强度不高，还需要开展更高
质量的一致性分析。

Abstract: Objective To compare the differences in the anterior chamber depth (ACD) measured by anterior segment optical
coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM). Methods All studies pertaining to ACD measured by
AS-OCT and UBM were collected from online databases. The assessment of methodological quality and data extraction from
the included studies were performed independently by two reviewers for meta-analysis. Results Eight studies involving 710
eyes were included in the analysis. The difference of ACD measurements between AS-OCT and UBM was not statistically
significant in the overall patients included for analysis (SMD=0.19, 95% CI ［0.00, 0.39］) or in the patients with primary
angle-closed glaucoma (SMD=0.02，95% CI［-0.04，0.19］). Conclusion The ACD measurements do not differ significantly
between AS-OCT and UBM. Due to the relatively small number of the included studies and the patients involved, this
conclusion needs further confirmation by high-quality studies involving larger sample sizes.