Abstract: Objective To analyze the renal relative blood flow value (rBFV) and image quality in normal adults using single-shot
fast spin echo, flow sensitive invention recovery (SSFSE-FAIR) magnetic resonance (MR) sequence and echo planar imaging,
and flow sensitive invention recovery (EPI-FAIR) MR sequence, and assess its value for clinical application in routine renal
examination. Methods Forty volunteers (25 male and 15 female adults, aged 30 to 62 years) with normal renal function were
included in this prospective study. All the subjects underwent 3.0 Tesla MR scanning using 3 MR scan modes, namely
breath-holding EPI-FAIR, breath-holding SSFSE-FAIR and free breathing SSFSE-FAIR. Results SSFSE-FAIR without
breath-holding was capable of differentiating the renal cortex and medulla with the corresponding rBFVs of 111.48±9.23 and
94.98 ± 3.38, respectively. Breath-holding SSFSE-FAIR and EPI-FAIR failed to distinguish the borders of the renal cortex and
medulla. The EPI-FAIR rBFV of mixed cortex and medulla value was 178.50 ± 17.17 (95% CI: 167.59, 189.41). Conclusion
Breath-holding SSFSE-FAIR and EPI-FAIR can not distinguish the renal cortex and medulla due to a poor spatial resolution but
can be used for rough evaluation of renal blood perfusion. Free breathing SSFSE-FAIR with an improved spatial resolution
allows evaluation of the status of renal perfusion of the cortex and medulla.