南方医科大学学报

南方医科大学学报 ›› 2013, Vol. 33 ›› Issue (09): 1347-.

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两种肾小球滤过率评价公式评价健康体检人群慢性肾脏病患病率的对比研究

杨沿浪，邹和群，汪裕伟，高潮清，陶青松，金岳龙   

  • 出版日期:2013-09-20 发布日期:2013-09-20

Comparison of two equations for calculating glomerular filtration rate in evaluation of the prevalence of chronic kidney disease in healthy population

  • Online:2013-09-20 Published:2013-09-20

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摘要： 目的对比研究两种肾小球滤过率（GFR）评价公式评价芜湖市健康体检人群慢性肾脏疾病（CKD）患病率以及CKD相关
独立危险因素。方法本研究截取40337名（男性24164名、女性16213名）的芜湖市单个健康体检中心健康体检人群，测量体
重、身高和血压，同时检测血常规、血糖、总胆固醇、甘油三脂、高密度脂蛋白、低密度脂蛋白、尿素氮、肌酐和尿酸及尿常规。结
果采用日本慢性肾脏病流行病学合作研究公式（J-EPI）公式和中国改良MDRD公式（C-MDRD）公式评价芜湖市城区CKD患
病率分别是3.9%和6.3%；与CKD相关独立危险因素为：年龄（≥60 岁）、高尿酸血症、高血糖。结论采用J-EPI 公式评价的
CKD患病率低于采用C-MDRD公式评价的CKD患病率；年龄（≥60岁）、高尿酸血症及高血糖为影响CKD流行率的高度相关
独立危险因素。

Abstract: Objective To compare two equations for calculating glomerular filtration rate (GFR) in the evaluation of the
prevalence of chronic kidney disease (CKD) and the risk factors of CKD in urban healthy population. Methods A total of 40377
subjects (24164 males and 16213 females) participated in this study. Body height, weight and blood pressure were measured,
and morning urine and venous blood samples were collected for routine urine and blood tests with measurements of blood
glucose, total cholesterol, high density lipoprotein (HDL), low-density lipoprotein (LDL), creatinine and uric acid. Results and
Conclusion Using Japanese CKD Epidemiology Collaboration (J-EPI) equation and Chinese modified Modification of Diet in
Renal Disease (C-MDRD) equation, the prevalence of CKD calculated was 3.9% and 6.3% in this population, respectively. The
independent risk factors of CKD included an age over 60 years, high uric acid, and high blood glucose.