南方医科大学学报

南方医科大学学报 ›› 2013, Vol. 33 ›› Issue (07): 1008-.

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Shh与MMP2在人食管鳞癌组织中的表达及意义

赵志龙，张丽芳，张佳，王健生   

  • 出版日期:2013-07-20 发布日期:2013-07-20

Expressions of Sonic hedgehog and maixmetallo proteinase 2 in human esophageal squamous cell carcinoma and the clinicopathological implications

  • Online:2013-07-20 Published:2013-07-20

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摘要： 目的探讨音猬因子（Shh）与基质金属蛋白酶2（MMP2）在人食管鳞癌组织中的表达以及与临床病理参数之间的关系。方
法采用免疫组化SP法检测Shh与MMP2在48例人食管鳞癌组织以及44例癌旁组织中的表达情况。结果Shh的阳性表达主
要定位在细胞质和胞核，在食管鳞癌组织中的阳性表达率为75%明显高于癌旁组织（20.45%），且与患者的TNM分期有关；而
MMP2的阳性表达主要分布在胞质，其在食管鳞癌组织中的阳性表达率为68.75%，明显高于癌旁组织中的22.72%，与淋巴结转
移与否，TNM分期有关，且均具有统计学意义（P<0.01）。48例人食管鳞癌组织中Shh蛋白与MMP2蛋白的表达呈正相关（R=
0.037，P=0.019）。结论Shh蛋白的表达可能参与到食管鳞癌的侵袭与转移。

Abstract: Objective To investigate the expressions of Sonic hedgehog (Shh) and maixmetallo proteinases 2 (MMP2) in human
esophageal squamous cell carcinoma (ESCC) and their association with the clinicopathological features. Methods
Immunohistochemistry was employed to examine the expressions of Shh and MMP2 in 48 specimens of ESCC and 44
specimens of adjacent tissues. Results The positivity rate of Shh expression in ESCC (75%) was significantly higher than that in
the adjacent tissues (20.45%). Shh expression was located mainly in the cell nuclei and cytoplasm, and was closely correlated
with TNM stage. Positive MMP2 expression was detected in 68.75% of the ESCC tissues as compared to 22.72% in the adjacent
tissues. MMP2 expression was localized mainly in the cytoplasm, and its expression level was closely correlated with TNM
stage and lymph node metastasis. A positive correlation was found between Shh and MMP2 expressions in the 48 ESCC tissues
(R=0.037, P=0.019). Conclusion The expression of Shh protein may be involved in tumor invasion and metastasis of ESCC.