南方医科大学学报

南方医科大学学报 ›› 2013, Vol. 33 ›› Issue (06): 937-.

• • 上一篇    

肝癌手术切缘Nusap1基因蛋白表达与早期复发的关系

张猛，杨定华，刘萧，刘延，梁鉴坤，何华，钟克波，林梁，陶国贵，张弛，周杰   

  • 出版日期:2013-06-20 发布日期:2013-06-20

Expression of Nusap1 in the surgical margins of hepatocellular carcinoma and its association with early recurrence

  • Online:2013-06-20 Published:2013-06-20

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摘要： 目的检测Nusap1基因蛋白在肝癌手术切缘中的表达情况及其与肿瘤早期复发的关系。方法选择常规病理学检查手术
切缘为阴性的原发性肝癌标本61例，用免疫组化法检测手术切缘Nusap1基因蛋白表达情况。结果肝癌手术切缘中Nusap1蛋
白表达阳性有21例，其中15例术后早期复发（71.4%）；阴性40例，术后仅12例出现早期复发（30%）；阳性组术后早期复发率明
显高于阴性组，差异有显著性（P<0.05）。结论肝癌手术切缘中Nusap1蛋白表达与术后早期复发明显相关，可预测肝癌术后早
期复发高危患者及指导术后辅助治疗。

Abstract: Objective To detect the expression of Nusap1 of surgical margins in hepatocellular carcinoma (HCC) and investigate
its association with early tumor recurrence. Methods The expression of Nusap1 in the surgical margins of HCC, which were
histopathologically negative for tumor cells, was examined using immunohistochemistry in 61 HCC cases. Results Fifteen of
21 (71.4%) cases with immunohistochemical positivity for Nusap1 expression in the surgical margins had early recurrence of
HCC, a rate significantly higher than that in patients with negative Nusap1 expression (12/40, 30%) (P<0.05). Conclusions
Nusap1 expression in the surgical margins of HCC is closely correlated to early postoperative recurrence and can serve as an
indicator for predicting early recurrence of HCC.