南方医科大学学报 ›› 2013, Vol. 33 ›› Issue (06): 934-.
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黄琴,赖伟男,杨敏
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摘要: 白塞病合并淋巴瘤病例罕见,目前国内外文献报道仅23例。本文报道国内第1例(世界上第2例)白塞病合并结外NK/T细胞淋巴瘤(鼻型)的病例,患者为26岁青年男性,确诊白塞病后予泼尼松龙、环磷酰胺、沙利度胺、生物制剂等药物治疗,自然病程2年后因急腹症手术,术后病理诊断“(回肠末端)结外NK/T细胞淋巴瘤,鼻型”。白塞病合并淋巴瘤的机制尚不清楚,本文通过文献复习,总结国内外报道的病例特点,在免疫机制、EB病毒感染、药物应用等方面对相关机制进行探讨。
Abstract: Malignant lymphoma complicated by Behcet’s disease (BD) is a rare clinical entity. We report a case of BDcomplicated by malignant lymphoma in a 26-year-old male patient. The patient was diagnosed to have terminal ileumextranodal NK/T-cell lymphoma (nasal type) during treatment for BD with cyclophosphamide (CTX), immunoregulants andbiological agents. This is the first case reported in China and the second case globally. The pathogenesis of BD complicated bymalignant lymphoma remains unclear. We reviewed the relevant literatures to summarize the clinical characteristics of BDcomplicated by extranodal NK/T-cell lymphoma (nasal type) and discuss the possible pathogenesis in light of immunology, EBvirus infection and medications.
黄琴,赖伟男,杨敏. 白塞病合并淋巴瘤1例报告并文献复习[J]. 南方医科大学学报, 2013, 33(06): 934-.
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