南方医科大学学报

南方医科大学学报 ›› 2013, Vol. 33 ›› Issue (06): 898-.

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分泌性白细胞蛋白酶抑制因子在结肠癌中的表达及其临床意义

郭久冰，李国新，庄建民，纪程宏，刘峰，陶国全，董汉章   

  • 出版日期:2013-06-20 发布日期:2013-06-20

Expression and clinical significance of secretory leucocyte protease inhibitor in colon carcinoma

  • Online:2013-06-20 Published:2013-06-20

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摘要： 目的探讨结肠癌组织中白细胞蛋白酶抑制因子（SLPI）的表达及其临床意义。方法选择150例结肠癌及癌旁正常组织
制成微阵列芯片作为研究对象，用免疫组织化学方法检测组织芯片中SLPI蛋白表达并评分，采用χ2检验比较不同SLPI表达水
平和结肠癌临床病理性特征，包括年龄、性别、组织分化程度、TNM分期、淋巴结转移及远处转移之间的关系。结果SLPI在结
肠癌组织中相对于正常结肠组织高表达，SLPI蛋白高表达与肿瘤分化［低分化：8（42.1%）vs 11（57.9%）；中/高分化：3（2.3%）vs
128（97.7%）、TNM分期：［Ⅲ~Ⅳ：25（29.4%）vs 60（70.6%）］、Ⅰ~Ⅱ：2（3.1%）vs 63（96.9%）、淋巴结转移［18（28.6%）vs 45
（71.4%）］及远处转移［11（84.6%）vs 2（15.4%）］相关（P<0.05），而与患者的性别和年龄差异无统计学意义（P>0.05）。结论SLPI
表达水平与肿瘤分化程度、TNM分期、淋巴结转移及远处转移有关，有可能作为判断结肠癌患者预后的指标。

Abstract: Objective To investigate the expression of secretory leucocyte protease inhibitor (SLPI) in colon cancer and their
clinical significance. Methods Immunohistochemistry was performed to detect the SLPI expression in colon cancer tissue
microarray. The expression of SLPI was scored by two pathologists and was analyzed using χ2 test to explore its influence on
the pathologic characteristics of colon carcinoma. Results SLPI was up-regulated in colon cancer tissue compared to normal
mucosa. Overexpression of SLPI protein was correlated with differentiation grade (low differentiation: 42.1% vs 57.9% ;
moderate/well differentiation: 2.3% vs 97.7%, TNM stages(III-IV:29.4% vs 70.6%;I-II:3.1% vs 96.9%), lymph node metastasis
(28.6% vs 71.4%) and distant metastasis (84.6% vs 15.4%), but not with patient age or sex. Conclusion SLPI overexpression
correlates with aggressive pathologic characteristics of colon cancer and it may server as prognostic factor of colon cancer
patients. Further research will be carried out to verify whether SLPI can become a new target for colon cancer treatment.