南方医科大学学报

南方医科大学学报 ›› 2013, Vol. 33 ›› Issue (06): 794-.

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Follicular immunoblastic lymphoma: a clinicopathologic and immunohistochemical study of a case

何选秋，杨磊，丁彦青   

  • 出版日期:2013-06-20 发布日期:2013-06-20

滤泡性免疫母细胞淋巴瘤临床病理分析

  • Online:2013-06-20 Published:2013-06-20

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摘要： 原发性滤泡性免疫母细胞淋巴瘤（FIBL）是种极少见的淋巴瘤，其免疫表型CD10阳性提示起源于生发中心，而CD138阳
性说明伴有浆母/浆细胞分化。为了更好地诊疗此病，本文从临床病理和免疫表型的特点方面报道国内首例女性患者，行
PET-CT检查明确全身淋巴结的累及情况，并分别与滤泡性淋巴瘤、反应性滤泡增生作鉴别诊断。FIBL作为滤泡性淋巴瘤的罕
见变异型，表现为滤泡内的肿瘤性免疫母细胞过度增生，向弥漫性大B细胞淋巴瘤的转化率略高于滤泡性淋巴瘤，预后较差，应
予重视。

Abstract: Primary follicular immunoblastic lymphoma (FIBL) is an extremely rare lymphoma. The positive expression of CD10
suggests the lymphoma originating from germinal centers (GC) and CD138-positve expression generally indicates
plasmablastic or plasmacytic differentiation. We report such a rare case in a Chinese female patient and analyze the
clinicopathologic and immunohistochemical features of this disease. PET-CT examination was performed to detect signs of
systemic lymph node metastasis. We also discussed the differential diagnosis of FIBL from follicular lymphoma (FL) and
reactive follicular hyperplasia (RFH). As a rare variant of human follicular lymphoma, FIBL is featured by a neoplastic
overgrowth of intrafollicular immunoblasts. Compared with FL, FIBL has a greater chance to evolve into diffuse large B-cell
lymphoma with therefore a poorer prognosis.