Abstract: Objective To investigate the correlation of G487A polymorphism of aldehyde dehydrogenase-2 (ALDH2) gene with
hypertension in patients with coronary heart disease complicated by type 2 diabetes. Methods This study was conducted
among 167 patients with coronary heart disease complicated by diabetes mellitus. The polymorphisms of gene G487A ALDH2
were determined using polymerase chain reaction-restricted fragments length polymorphism technique (PCR-RFLP).
According to the genotypes, the patients were divided into GG group (n=105) and GA/AA group (n=62), and the incidence of
hypertension, risk factors of hypertension, systolic and diastolic pressures, and pulse pressure indexes were compared
between the two groups. Multivariate logistic regression analysis was performed to adjust the effects of the confounding
factors. Results The incidence of hypertension in GA/AA group was significantly higher than that in GG group (P<0.05), and
the former group showed a significantly greater differences between systolic and pulse pressure; the diastolic pressure was
comparable between the two groups. Multivariate logistic regression analysis showed that GA/AA was associated with an
increased risk of hypertension in synergy with high insulin level and insulin resistance. Conclusion ALDH2 gene G487A
polymorphism may be associated with hypertension in patients with coronary heart disease complicated by type 2 diabetes,
and the patients with an Aallele have a greater risk of developing hypertension.