南方医科大学学报

南方医科大学学报 ›› 2013, Vol. 33 ›› Issue (01): 150-.

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血清中sFas水平的动态变化与急性一氧化碳中毒后迟发性脑病的关系

张萍，韩永凯，赵国有，顾家鹏，魏蕤荭，顾仁骏，王传升   

  • 出版日期:2013-01-20 发布日期:2013-01-20

Relationship between changes of serum soluble Fas levels and delayed encephalopathy after acute carbon monoxide poisoning

  • Online:2013-01-20 Published:2013-01-20

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摘要： 目的观察血清中可溶性细胞凋亡调节蛋白（sFas）的水平及其动态变化是否参与了急性一氧化碳中毒后迟发性脑病
（DEACMP）的发生与发展，探索DEACMP可能的发病机制及加重机制。方法收集40例DEACMP患者，分别在发病急性期、
恢复期各取血清3 ml，采用酶联免疫吸附法测定sFas水平；收集同期健康老年人36例，取同等量血清进行同样测定，作为对照
组进行比较。结果（1）DEACMP患者发病急性期血中sFas含量与正常组无明显差别（P=0.737）；（2）DEACMP患者加重期血
中sFas 含量与健康对照组比较无明显差别（P=0.137）；（3）DEACMP组发病急性期血清中sFas 含量与恢复期无明显差别（P=
0.059）。结论sFas似乎未参与DEACMP的发生，对其病情加重及发展也没有明显影响。

Abstract: Objective By explore the role of serum soluble Fas (sFas) in occurrence and progression of delayed encephalopathy
after acute carbon monoxide poisoning (DEACMP). Methods Enzyme-linked immunosorbent assay (ELISA) was used to
detect serum sFas levels in 40 patients with DEACMP in acute stage and convalescent stage, with 36 healthy elderly subjects as
the control group. Results Serum sFas levels of the patients with DEACMP in both the acute and convalescent stages showed
no significant difference from those in the control group (P=0.737 and 0.137, respectively), nor was any significant difference
found between the patients in acute and exacerbation stages (P=0.059). Conclusion Serum sFas is not involved in the
occurrence and progression of DEACMP.