南方医科大学学报

南方医科大学学报 ›› 2012, Vol. 32 ›› Issue (10): 1451-.

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脓毒症患者血清IL-6与脑损伤的相关性分析

刘占国，谭晓莹，蔡靓，杨祥锐，常平   

  • 出版日期:2012-10-20 发布日期:2012-10-20

Correlation analysis between serum interleukin-6and central nervous injury in septic patients

  • Online:2012-10-20 Published:2012-10-20

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摘要： 目的探讨脓毒症患者血清白细胞介素-6(IL -6)水平与中枢神经损伤的关系。方法选择符合脓毒症诊断标准同时无中枢
神经系统疾病的患者22例作为研究对象，检测血清IL-6和神经元特异性烯醇化酶（NSE）水平，并根据IL-6的水平分为低中高3
个浓度组，比较3个浓度组NSE水平及急性生理和慢性健康（APACHEII）评分的差异，分析血清IL-6与NSE及APACHEII的
相关性。结果IL-6低中高3个浓度组NSE水平具有显著性差异（P<0.001），浓度分别为(10.29±4.05)、(16.06±5.84)、(23.97±
3.28)μg/L。IL-6三个浓度组的APACHEII评分同样具有显著性差异（P=0.009），分值分别为14.17±4.67、16.40±4.84和24.00±
6.26。相关性分析显示IL-6与NSE和APACHEII评分均具有显著的正相关性，相关系数分别为r=0.788(P<0.001)和0.733(P<
0.001)。结论脓毒症患者血清IL-6的浓度同患者危重程度和中枢神经损伤均有显著地相关性，可以作为动态监测脓毒性脑损
伤的标志物。

Abstract: ObjectiveTo explore the relationship between interleukin-6(IL-6) production and central nervous injury in septic
patients.MethodsTwenty-two septic patients without central nervous system diseases were examined for serum IL-6and
neuron-specific enolase (NSE) levels, and the serum NSE levels and APACHEII scores were compared between patients with
low, moderate, and high serum IL-6levels. The correlations between NSE, APACHEII and serum IL-6were analyzed.Results
In patients with low, moderate, and high serum IL-6levels, the serum levels of NSE were10.29±4.05, 16.06±5.84and23.97±3.28
μg/L, respectively, showinga significant difference betweenthe 3 groups (P<0.001). The APACHEII scores also differed
significantly between the3groups (14.17±4.67, 16.40±4.84, and 24.00±6.26, respectively, P=0.009). Correlation analysis showed
significant positive correlations of IL-6with NSE (r=0.788, P<0.001) and with APACHEII scores (r=0.733, P<0.001).Conclusion
In septic patients, serum IL-6level is significantly correlated with the severity of sepsis and brain injury, and can be used as a
marker to monitor brain injury in septic patients.