南方医科大学学报

南方医科大学学报 ›› 2012, Vol. 32 ›› Issue (10): 1427-.

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重离子辐照对荷颊囊癌金黄地鼠血清IL-2水平的影响

安晓莉，司庆宗，刘斌，张红   

  • 出版日期:2012-10-20 发布日期:2012-10-20

Effect of heavy ion beam irradiation on serum interleukin-2level in a hamster model bearing cheek pouch carcinoma

  • Online:2012-10-20 Published:2012-10-20

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摘要： 摘要：目的通过检测重离子辐照前后荷颊囊癌金黄地鼠外周血血清中白细胞介素-2（IL-2）水平变化，探讨重离子束辐照对机体
免疫状态的影响。方法应用酶联免疫吸附法检测40例荷瘤组及8例空白对照组经重离子束辐照前后血清IL-2水平变化。结
果荷瘤（0Gy）组血清IL-2水平为0.16±0.01，较空白对照组水平低；而荷瘤辐照组经4、6、8、12Gy辐照后IL-2水平分别0.18±
0.04、0.22±0.05、0.15±0.03和0.13±0.04；辐照后血清IL-2水平先出现升高趋势，至6Gy组时达到最高，之后随辐照剂量的增大而
降低，至12Gy时仍低于空白对照组水平。结论重离子束辐照对荷颊囊癌金黄地鼠血清中IL-2表达水平产生影响，存在一定的
量效关系。

Abstract: ObjectiveTo investigate the changes in serum interleukin-2(IL-2) level in a hamster model bearing cheek pouch
carcinoma after heavy ion beams irradiation. MethodsThe serum levels of IL-2 were detected using enzyme-linked
immunosorbant assay in40hamsters bearing cheek pouch carcinoma before and after exposure to heavy ion beam irradiation,
with8normal animals as control.ResultsSerum IL-2level was0.16±0.01in the tumor-bearing hamsters before the irradiation,
lower than that in the control group. After heavy ion beams irradiation at 4, 6, 8, and 12Gy, serum IL-2levels in the
tumor-bearing hamsters were0.18±0.04, 0.22±0.05, 0.15±0.03, and 0.13±0.04, respectively, showing a peak level after irradiation
at6Gy and an obvious decrease following irradiation at greater doses.ConclusionHeavy ion beam irradiation causes
alterations in serum IL-2level with a dose-effect relation between them in hamsters bearing cheek pouch carcinoma.